Inhibitory effect of oral films containing paracress extract and oral-derived probiotics on halitosis and oral pathogenic bacteria

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010244

Enrollment

Registered

2025-02-28

Start date

2024-09-05

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Dietary Supplement : Experimental group: DocsBiome Orafil (Docsmedi Co., Ltd., South Korea) should be consumed by placing one film on the tongue and letting it dissolve slowly three times a day after

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals with measurements within the reference range on a halitosis measuring device (H2S: 1.5 or higher but less than 12, or CH3SH: 0.5 or higher but less than 9). Individuals with no history of using halitosis-relief products (e.g., tongue cleaners, oral films) within the past 7 days. Individuals who agree to participate in the study and can maintain consistent lifestyle habits throughout the study period (7 days).

Exclusion criteria

Exclusion criteria: Smokers Individuals who have used tongue cleaners within the past 7 days Individuals who have used oral dissolving films within the past 7 days Individuals requiring treatment for severe dental conditions (e.g., periodontitis, dental caries, xerostomia, peri-implantitis) as of the visit date Individuals currently undergoing treatment for severe cardiovascular, immune, respiratory, gastrointestinal/biliary, nervous, musculoskeletal, infectious diseases, or malignancies Individuals with clinically significant cardiovascular, immune, infectious, or malignant diseases Individuals with uncontrolled hypertension (=160/100 mmHg) Individuals with uncontrolled diabetes (fasting blood glucose =180 mg/dL or initiation of diabetes medication within the past 3 months) Individuals with mental illnesses such as schizophrenia, depression, drug addiction, or alcohol addiction Individuals with a history of bleeding disorders, conditions, or those taking antiplatelet or anticoagulant medications for prevention Pregnant women or women preparing for pregnancy Breastfeeding women Women within 6 months postpartum Individuals with a known allergy to Spilanthes acmella extract or oral-derived lactic acid bacteria

Design outcomes

Primary

Measure	Time frame
Hydrogen sulfide (H2S) & Methyl mercaptan (CH3SH)	—

Secondary

Measure	Time frame
Bacterial copy number of oral pathogens (P. gingivalis, T. forsythia, T. denticola, P. intermedia, C. rectus, F. nucleatum, S. mutans)	—

Countries

Korea, Republic of

Contacts

Public ContactMUYEOL CHO

Apple Tree Medical Foundation

whanduf@appleden.com+82-70-4601-5479

Outcome results