Efficacy of Submucosal Polydeoxyribonucleotide (PDRN) Injection After Impacted Mandibular Third Molar Extraction, A Randomized Controlled Trial

Comparison of the Postoperative Effects of PDRN (Polydeoxyribonucleotide) on Swelling, Pain Reduction, and the Healing Pattern of Oral Mucosal Tissue Following the Extraction of Impacted Third Molars: A Clinical Comparative Study to Prove the Superiority of PDRN

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010231

Enrollment

Registered

2025-02-21

Start date

2024-10-10

Completion date

Unknown

Last updated

2025-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Polydeoxyribonucleotides (PDRN), derived from the sperm of Oncorhynchus mykiss or Oncorhynchus keta are low molecular weight DNA fragments known for their ability to 1) stimulate cell migration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: -Bilateral IMTMs with similar difficulty -Underlying medical conditions well managed

Exclusion criteria

Exclusion criteria: -Autoimmune diseases, hemorrhagic disorders, psychiatric disorders or those suspected of having psychiatric disorders. -History of hypersensitivity to polydeoxyribonucleotide (PDRN) -Pregnant or breastfeeding women -Malignant tumors or those undergoing chemotherapy -Alcohol dependency -Any other individuals inappropriate for participation in the clinical study based on the researcher's judgment.

Design outcomes

Primary

Measure	Time frame
Postoperative Pain	—

Secondary

Measure	Time frame
Pocket Probing Depth;Patient Centered Outcome Questionnaire((Pain, whether additional painkillers were taken, subjectively perceived level of facial swelling, intraoral bleeding, intraoral discomfort, pronunciation, and mouth opening amount are divided into left and right and evaluated by dividing them into never/hardly ever/occasionally/fairly often/very often);pain duration time;Postoperative swelling	—

Measure

Time frame

Pocket Probing Depth;Patient Centered Outcome Questionnaire((Pain, whether additional painkillers were taken, subjectively perceived level of facial swelling, intraoral bleeding, intraoral discomfort, pronunciation, and mouth opening amount are divided into left and right and evaluated by dividing them into never/hardly ever/occasionally/fairly often/very often);pain duration time;Postoperative swelling

—

Countries

Korea, Republic of

Contacts

Public ContactHyun Joong Kim

Yonsei University, Wonju Severance Christian Hospital

khj04537@naver.com+82-31-741-0114

Outcome results