None listed
Conditions
Interventions
Dietary Supplement : Treatment group
- Study drug : LB-P12 350mg(LB-P12 233mg/day), etc.
- Once a day, once a capsule, take it with water after dinner, 12 weeks
Placebo group
- placebo : 350mg of Myc
Sponsors
LISCure Biosciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults under the age of 40 to 75 regardless of gender 2. Visual Analysis Scale (VAS) 3/10 or higher 3. A person whose Kellgren & Lawrence grading scale falls under grade 1 or 2 due to "Both Knee Joint AP" 4. A person who has consented to the test consent written by the applicant as a subject of this test because normal physical activity is possible
Exclusion criteria
Exclusion criteria: 1. Those who have a history of bone fractures within the past year 2. Those who have a torn meniscus 3. Those who have periarticular bone spurs, irregular joint surfaces, and subchondral cysts, and assessed to have moderate osteoarthritis 4. Those who have used COX-2 inhibitors, NSAIDs, or joint-impacting supplements (e.g., glucosamine, green-lipped mussel oil complex, Boswellia extract, chondroitin, MSM, vitamin D, collagen, turmeric extract, or Taibo extract) within 4 weeks before screening, or plan to take them during the study 5. Those who have taken probiotics or lactic acid bacteria within 2 weeks before screening 6. Those who currently undergoing treatment for thyroid disorders 7. Those with kidney disease or a serum creatinine level of 1.4 mg/dL or higher 8. Those who have proteinuria of 2+ or higher 9. Those with liver disease or AST/ALT levels of 100 IU/L or higher 10. Those with uncontrolled hypertension or cardiovascular conditions, such as angina or myocardial infarction 11. Those taking medication for psychiatric disorders (intermittent sleep medication is excluded) 12. Those who have taken herbal or traditional medicine within the past 2 months 13. Those who have taken any investigational drugs within the last 4 weeks 14. Those requiring ongoing medications that could potentially impact the study results 15. Those with a history of gastrointestinal surgery (except appendectomy) 16. Pregnant or breastfeeding individuals 17. Those with alcohol dependency or those who consume alcohol four or more times per week 18. Those with known allergies to the test product or its components 19. Those deemed uncooperative or otherwise unsuitable for study participation, as assessed by the researcher 20. Those whom the principal investigator determines to have arthritis caused by factors other than degenerative conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC(Western Ontario and McMaster Universities) questionnaire total score/pain/joint stiffness/physical function score variation | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS(Visual Analogue Scale);Anti-inflammatory indicators (CRP concentration, ESR);inflammatory indicator(IL-1ß, IL-6, TNF-a) ;serum COMP concentration;Joint space width;Quality of Life Survey (EQ-5D-5L) | — |
Countries
Korea, Republic of
Contacts
Public ContactHan seong ho
Dong-A University
Outcome results
None listed