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Effect of low tidal volume ventilation strategy on intraoperative bleeding undergoing laparoscopic hepatectomy in liver cancer patients

Effect of low tidal volume ventilation strategy combined goal -directed fluid therapy on intraoperative bleeding undergoing laparoscopic major hepatectomy in liver cancer patients: a multicenter surgeon blinded randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0010188
Enrollment
58
Registered
2025-02-12
Start date
2022-10-12
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : The study participants will be randomly assigned to either the traditional tidal volume group (tidal volume [mL] = ideal body weight [kg] * 10–12) or the low tidal volume group (ti

Sponsors

Seoul National University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients aged 19 years or older and under 80 years. Patients scheduled to undergo laparoscopic major hepatectomy for liver cancer. Major hepatectomy is defined as the resection of three or more liver segments or non-anatomical resection of 30% or more of the liver. Patients must be able to provide written informed consent to participate in the clinical trial, understand the procedures of the study, and be capable of appropriately completing patient-reported questionnaires.

Exclusion criteria

Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: American Society of Anesthesiologists (ASA) physical status of 4 or higher. Patients with chronic obstructive pulmonary disease (COPD). Patients with a Child-Turcotte-Pugh (CTP) score of C. Patients with arrhythmia. Patients deemed unsuitable for participation in the clinical trial based on the investigator’s or study coordinator’s judgment. Cases where the procedure is converted to open surgery.

Design outcomes

Primary

MeasureTime frame
Introperative blood loss

Secondary

MeasureTime frame
Postoperative pulmonary complications (atelectasis and pneumonia);Postoperatvie laboratory data ;Surgeon and anesthesiologist satisfaction scale (rated from 0 = easy to 10 = difficult)

Countries

Korea, Republic of

Contacts

Public ContactYong-Hee Park

Asan Medical Center

dada822@naver.com+82-2-3010-3868

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026