A Study on the Effects of Mild Electrical Stimulation on Memory Improvement in Patients with Mild Cognitive Impairment and Early Alzheimer's Disease

A single-center, crossover designed, active control, double-blinded study for comparative evalu ation of the cognitive function improvement effects of transcranial alternating current stimulati on at different frequencies in individuals with mild cognitive impairment or early Alzheimer’s dis ease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010158

Enrollment

Registered

2025-01-24

Start date

2024-02-26

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : This study employs a randomized, active-controlled clinical design where participants are randomly assigned to one of three transcranial stimulation conditions: sham tACS (control), t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 55 years or older. 2. Patients meeting the diagnostic criteria for mild cognitive impairment (MCI), with or without accompanying depression. This includes patients scoring 0.5–2 on the Clinical Dementia Rating (CDR) scale or 2–5 on the Geriatric Depression Scale (GDS), who: - Complain of memory decline (memory complaint), - Have normal activities of daily living, - Demonstrate normal general cognitive function, - Show abnormal memory for age, - Are not diagnosed with dementia, or have been diagnosed with Alzheimer’s dementia. 3. Individuals capable of reading, understanding the participant information sheet and consent form, and responding to questionnaires with adequate language skills. 4. Individuals who voluntarily decide to participate in this clinical trial, provide written informed consent, and are available for participation throughout the study duration.

Exclusion criteria

Exclusion criteria: 1. Individuals diagnosed with bipolar disorder or psychotic major depressive disorder. 2. Individuals with a history of Axis I psychiatric disorders, including intellectual disability, schizophrenia, alcohol dependence, or bipolar disorder. 3. Individuals with medical conditions that may interfere with completing the study, such as stroke, seizure disorders, Parkinson’s disease, multiple sclerosis, cerebral palsy, Huntington’s disease, encephalitis, meningitis, severe liver disease (e.g., cirrhosis), or kidney disease requiring dialysis. 4. Individuals with a history of seizures. 5. Individuals with other neurological abnormalities identified through medical examinations that could cause memory impairment. 6. Individuals with scalp deformities, inflammatory reactions, or other dermatological conditions that may interfere with the placement of EEG or stimulation electrodes. 7. Individuals with a history of cancer within the past three years. 8. Individuals who have undergone brain surgery, carotid artery surgery, or other cerebrovascular procedures. 9. Individuals who experience shortness of breath while seated. 10. Individuals with a history of drug abuse within the past five years.

Design outcomes

Primary

Measure	Time frame
Cognitive Function test(Digit Span; Trail-making test;)	—

Secondary

Measure	Time frame
Resting EEG	—

Countries

Korea, Republic of

Contacts

Public ContactSeungchan Park

Hallym University Medical Center- Chuncheon

psc5436@gmail.com+82-33-240-5313

Outcome results