None listed
Conditions
Interventions
Medical Device, Procedure/Surgery : 1. Accelerated Initiation of CRRT Group: Definition: After random assignment, continuous renal replacement therapy (CRRT) is initiated as soon as possible, ideally
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subject must be at least 19 years of age. Patients presented with CS (Society for Cardiovascular Angiography and Interventions [SCAI] Shock classification C, D or E) * who requiring VA-ECMO. Classic CS (Stage C) was defined as the following criteria. A. Systolic blood pressure less than 90 mmHg for more than 30 min or catecholamines required to maintain pressure more than 90 mmHg during systole. B. Sign of pulmonary congestion C. Sign of impaired organ perfusion with at least one of the following: altered mental status. cold, clammy skin and extremities. oliguria with urine output 2.0 mmol/l. SCAI Shock classification D is defined as failure to respond to initial interventions with clinical deterioration of classic CS or SCAI Shock classification E is defined as cardiac arrest with ongoing cardiopulmonary resuscitation requiring VA-ECMO Patients in the first 48 hours of CS developing AKI with at least one criterion (Characteristic of the stage 2 AKI according to Kidney Disease: Improving Global Outcomes [KDIGO] classification) A 2-fold or over increase in serum creatinine relative to baseline A reduction in urine output of =0.5 ml/kg/h for = 12 hours
Exclusion criteria
Exclusion criteria: Other causes of shock (hypovolemia, sepsis, obstructive shock). Criteria mandating CRRT initiation: acute kidney injury prior to enrollment caused by any reason, at least one of the following criteria is met. serum potassium > 6.5 mmol/L serum potassium> 6.0 mmol/L persisting despite medical treatment. metabolic acidosis (pH < 7.15 and PaCO2 < 35 mmHg or serum bicarbonate < 12 mmol/L) blood urea nitrogen level =100 mg/dL. diuretics refractory volume overload or pulmonary edema Unwitnessed out-of-hospital cardiac arrest with persistent Glasgow coma scale <8 after the return of spontaneous circulation. Chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR)<30 mL/min/1.73m2 or end-stage kidney disease under dialysis Kidney transplant within the past 365 days Receipt of any RRT in the preceding 2 months Known heparin intolerance. Other severe concomitant disease with limited life expectancy < 6 months Pregnancy or breastfeeding Do not resuscitate wish. Presence of a drug overdose or dialyzable toxin that necessitates RRT. Presence or strong clinical suspicion of post-renal AKI duet to obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy or acute interstitial nephritis Clinical decision by a responsible physician to immediately start RRT. Clinical decision by a responsible physician to defer RRT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause mortality or RRT dependence | — |
Secondary
| Measure | Time frame |
|---|---|
| in-hospital mortality;in-hospital cardiac mortality;Cerebral Performance Category 3-5;all-cause mortality;cardiac mortality;Requirement of cardiac replacement therapy;re-hospitalization due to heart failure;re-hospitalization due to any cause;cerebrovascular accident | — |
Countries
Korea, Republic of
Contacts
Public ContactJeong Hoon yang
Samsung Medical Center
Outcome results
None listed