To compare strategies for administering tranexamic acid in noncardiac surgery patients at high risk for perioperative bleeding.

Comparison of viscoelastic test-guided and preemptive tranexamic acid administration strategies in high-risk non-cardiac surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0010069

Enrollment

Registered

2024-12-20

Start date

2024-12-27

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Intraoperative TXA will be administered as follows. In the study group, if there is more than 5 ml/kg or more than 300 ml of blood loss, a TEG6 test is performed and TXA 10 mg/kg is administe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Inclusion Criteria (1) Age 19 years or older (2) Patients scheduled for non-cardiac surgery with high bleeding risk Spinal fusion surgery at level 2 or above Artificial joint replacement: hip, knee, etc. Prostatectomy Cystectomy Hepatectomy Non-cardiac surgery with high bleeding risk (3) Signed consent to participate in the study

Exclusion criteria

Exclusion criteria: 2) Exclusion Criteria 1) Pregnant women 2) Patients who refuse blood transfusion 3) Patients receiving thrombin 4) Patients with a history of thromboembolism and familial hypercoagulable disease within 90 days 5) Patients with a history of myocardial infarction or ischemic stroke within 90 days 6) Patients with hypersensitivity to TXA 7) Patients with a history of convulsions and epilepsy 8) Patients undergoing dialysis for end-stage renal failure 9) Other patients deemed unsuitable for the study by the investigators 10) Patients already assigned to a study arm who develop additional intraoperative bleeding and subsequent change in whether or not to receive TXA, rendering prior arm assignment meaningless

Design outcomes

Primary

Measure	Time frame
- CRT MA (mm)	—

Secondary

Measure	Time frame
Postoperative TEG 6 test value changes: CK r-time (min), CK a-angle (°), CRT MA (%), CRT LY30 (%), CFF MA (mm) Postoperative changes: hemoglobin, platelet, central laboratory coagulation tests (if available)	—

Countries

Korea, Republic of

Contacts

Public ContactHa Jung Kim

Asan Medical Center

alexakim06@gmail.com+82-2-3010-0338

Outcome results