None listed
Conditions
Interventions
Drug : * Test group: Local antibiotic ointment (2% minocycline hydrochloride, Periocline®, Sunstar, Osaka, Japan, 1 syringe (5g)) applied to peri-implant mucosal sulcus four times at one-week interva
Sponsors
Jeonbuk National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. participants aged 19 years or older. 2. a confirmed diagnosis of peri-implantitis, defined as the presence of bleeding and/or pus on gentle probing, with probing depth = 6 mm and bone loss = 3 mm. 3. selection of only one peri-implantitis site, specifically the site with the highest severity, as the target for enrolment. 4. willingness to provide informed consent for study participation.
Exclusion criteria
Exclusion criteria: 1. heavy smokers (=20 cigarettes/day). 2. adverse reactions or allergy to minocycline and/or chlorhexidine mouthwash 3. pregnancy or lactation 4. uncontrolled medical conditions including diabetes or hypertension. 5. history of alcohol or drugs abuse 6. a history of prior treatment of the target area, either surgical treatment at least 6 months prior or non-surgical treatment at least 3 months prior. 7. use of antibiotics for periodontal and/or peri-implant disease in the past three months, 9) use of medications that may affect periodontal and/or peri-implant disease, including anticonvulsants, immunosuppressive agents, and calcium channel antagonists. 8. poor or uncontrolled oral hygiene.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peri-implant probing depth | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone Loss;Microbial analysis;Peri-implant buccal profile | — |
Countries
Korea, Republic of
Contacts
Public ContactJae-Hong Lee
Jeonbuk National University Hospital
Outcome results
None listed