None listed
Conditions
Interventions
Drug : We will observe the effect of certain MAC (minimal alveolar concentration) of sevoflurane on motor evoked potentials amplitude reduction. The clinical criteria is amplitude reduction more than
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) American society of Anesthesiology physical status 1-3 2) 20 =adults < 80 3) Patients who are scheduled for elective cervical spine operation with intraoperative motor evoked potentials in Orthopedic surgery department.
Exclusion criteria
Exclusion criteria: 1) Preoperative neurological deficit, particularly, muscle strength grade < 3 2) Ejection fraction < 40% or significant aortic regurgitation or significant arrhythmia 3) Abnormal pulmonary function test: more than moderate obstructive or restrictive pattern 4) Patients with tolerance or hypersensitivity to benzodiazepine 5) Patients with dependence or addiction to psychotropic drugs or alcohol 6) Patients with previous brain-related neurosurgery 7)Patients with inserted status of intracranial device 8)Pregnant and lactating women 9)Patients with pacemaker insertion which may interfere evoked potentials test 10)Patients with acute narrow angle glaucoma 11)Patients with moderate hypersensitivity to Dextran40 12)Patients with history of malignant hyperthermia or having genetic susceptible malignant hyperthermia 13)Previous hypersensitivity history to halogenated inhalation agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 of sevoflurane: 'sevoflurane concentration' suppress more than 50% of MEP amplitude in half of the subjects | — |
Countries
Korea, Republic of
Contacts
Public ContactHee Sun Park
Asan Medical Center
Outcome results
None listed