None listed
Conditions
Interventions
None listed
Sponsors
Pusan National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: #Patients ? Early onset AD ? Onset age between 19-64 years ? Meets DSM-V criteria for Dementia (American Psychiatric Association. 2013) ? Meets NIA-AA criteria for Probable AD dementia (McKhann et al., 2011) ? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers ? Must have a caregiver who can provide information about the participant’s cognitive and functional performance ? Willing and able to consent to the protocol ? Early onset MCI ? Onset age between 19-64 years ? Memory or cognitive functions complaint, preferably corroborated by an informant ? Preserved activities of daily living ? Not demented ? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers ? Must have a caregiver who can provide information about the participant’s cognitive and functional performance ? Willing and able to consent to the protocol ? Early SCD ? Onset age between 19-64 years ? Subjective cognitive impairment ? Meets criteria for cognitively normal, based on neuropsychological test ? Amyloid positive status (PET scan) or A+T+N+ status based on CSF AD biomarkers ? Willing and able to consent to the protocol ? FTD ? Onset age between 19-64 years ? Meets criteria for bvFTD (Rascovsky et al., 2011) ? Meets criteria for svPPA (Gorno-Tempini et al., 2011) ? Meets criteria for nfvPPA (Gorno-Tempini et al., 2011) ? Meets El Escorial criteria for MND combined with FTD ? Must have a caregiver who can provide information about the participant’s cognitive and functional performance ? Willing and able to consent to the protocol ? Other EOD ? Onset age between 19-64 years ? Leukodystrophy ? Early onset neurodegenerative dementia other than FTD or EOAD ? Other unspecified EOD ? Must have a caregiver who can provide information about the participant’s cognitive and functional performance ? Willing and able to consent to the protocol # Family Members ? Family members whose patient has known pathogenic mutations, two or more first degree family members with EOD, or one or more family member with EOD for 3 generations ? Willing and able to consent to the protocol
Exclusion criteria
Exclusion criteria: ? History of major psychiatric disorders (schizophrenia, major depression, bipolar disorders, alcohol/substance abuse, delirium, etc.) ? History of cerebral infarction, cerebral hemorrhage, brain tumor or systemic disease which could affect cognitive functions ? Contraindications to MRI or CT (e.g., claustrophobia, pacemaker, select aneurismal clip, metal fragments, or ventriculoperitoneal shunt, etc.) ? Illiteracy ? Pregnant or lactating ? Deemed ineligible by the site PI for any other reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demographic data, Clinical data (neuropsychological tests, blood test, brain MRI, PET, WES) | — |
Secondary
| Measure | Time frame |
|---|---|
| no data | — |
Countries
Korea, Republic of
Contacts
Public ContactMin Su GO
Pusan National University Hospital
Outcome results
None listed