None listed
Conditions
Interventions
Drug : Patients who consented to participate in the study were randomly assigned to either the ATG group or the PTCY group. Randomization was done in a permuted block design with a pre-assigned block
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Selection criteria • Patients aged 18 years or older • Patients with adequate liver and renal function who meet the following conditions - AST, ALT, and direct bilirubin < 2.5 x upper limit of normal - Serum creatinine < 2.0 mg/dL and creatinine clearance = 40 mL/min) • Patients who agreed to participate in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria • Patients with a history of allogeneic hematopoietic stem cell transplantation or autologous hematopoietic stem cell transplantation for leukemia or other malignant tumors • Blast crisis of chronic myeloid leukemia • Patients with a history of other active malignancies within 5 years prior to clinical trial participation, excluding past or current curatively treated basal cell skin cancer or past cervical intraepithelial carcinoma • Patients with uncontrolled infections • Women of childbearing potential, pregnant women, or lactating women who do not wish to use adequate contraception • Patients who, in the investigator's judgment, may pose a risk to patient safety
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Acute Graft-versus-Host Disease;Incidence of Chronic Graft-versus-Host Disease;Cumulative incidence of Acute Graft-versus-Host Disease;Cumulative incidence of Chronic Graft-versus-Host Disease;Leukocyte engraftment date;Platelet engraftment date;Complete donor chimerism attainment rate;CMV, EBV reactivation rate;Total number of repeat calls;Recurrence-free survival rate;Overall survival rate | — |
Secondary
| Measure | Time frame |
|---|---|
| hematologic relapse;Molecular recurrence | — |
Countries
Korea, Republic of
Contacts
Public ContactKyung-Hwa Lee
Asan Medical Center
Outcome results
None listed