None listed
Conditions
Interventions
None listed
Sponsors
Daejeon Korean Medicine Hospital of Daejeon University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Men and women aged 50 to 85 2) Clinically diagnosed with Alzheimer's disease, a major neurocognitive disorder due to vascular disease, or mild neurocognitive disorder (based on DSM-5 criteria) 3) Participants who have provided written consent themselves or through their legal representative for clinical research
Exclusion criteria
Exclusion criteria: 1) Individuals with cognitive impairment due to neurodegenerative diseases such as Parkinson's disease, Huntington's disease, frontotemporal dementia (FTD), or Creutzfeldt-Jakob disease. 2) Individuals with a history of systemic diseases that lead to dementia, including but not limited to hypothyroidism, vitamin B12 or folic acid deficiency, niacin deficiency, neurosyphilis, or HIV-related neurocognitive disorders known to cause or contribute to cognitive decline. 3) Individuals with a history of major mental illnesses diagnosed under DSM-5, including but not limited to schizophrenia, delusional disorder, bipolar disorder, or substance-related disorders (including alcohol and other substances). 4) Individuals with a history of neurological disorders such as epilepsy, focal brain damage, or head trauma. 5) Individuals with gastrointestinal, endocrine, or cardiovascular diseases that are difficult to manage or not adequately controlled through diet or medication. 6) Individuals deemed to be in a serious and unstable health condition by the attending clinician, based on clinical pathology tests, electrocardiogram (EKG) results, chest X-ray, vital signs, and other related medical evaluations. 7) Individuals considered unsuitable for participation in this clinical study according to the researcher’s judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment-Korean version(MoCA-K);Korean-Dementia Rating Scale(K-DRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate Variability (HRV);Clinical Dementia Rating Scale(CDR);Global Deterioration Scale(GDS);Short-form Geriatric Depression Scale(SGDS);Korean version of Instrumental Activity of Daily Living(K-IADL);Neuropsychiatric Inventory–Questionnaire(NPI-Q);Pattern Identifications Tool for Cognitive Disorders(PIT-C);The 5-level EuroQol-5 Dimension(EQ-5D-5L);Clinical pathway applicability indicators | — |
Countries
Korea, Republic of
Contacts
Public ContactMira Hur
Daejeon Korean Medicine Hospital of Daejeon University
Outcome results
None listed