None listed
Conditions
Interventions
None listed
Sponsors
Apple Tree Medical Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Individuals aged 40 to 79 years Those diagnosed with severe periodontal disease requiring the extraction of four or more teeth (observation group criteria) Those with oral health in good condition, not requiring any separate dental treatment (control group criteria)
Exclusion criteria
Exclusion criteria: Individuals who have taken antibiotics within the last month Pregnant women and women planning to become pregnant Breastfeeding women Women within six months postpartum Individuals who have participated in another clinical study within the last month Individuals deemed unsuitable for participation in the study by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The levels of six bacteria (P. gingivalis, T. denticola, T. forsythia, P. intermedia, C. rectus, F. nucleatum) based on Shotgun and 16s rRNA test results. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anti-inflammatory markers (IL-1ß, TNF, MMP, IL-1A, IL-1B, IL-6, IL-10, MMP-3, MMP-9, inflammatory gene methylation, miRNA), age, socioeconomic status, lifestyle habits, oral hygiene habits, dietary habits. | — |
Countries
Korea, Republic of
Contacts
Public ContactMu-Yeol Cho
Apple Tree Medical Foundation
Outcome results
None listed