None listed
Conditions
Interventions
Dietary Supplement : Names: Lactobacillus plantarum DSR920 and Lacticaseibacillus rhamnosus DM163.
Dosage: Each dose contains 7.5E10 CFU of L. plantarum DSR920 and 2.5E10 CFU of L. rhamnosus DM163.
Fr
Sponsors
Apple Tree Medical Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Individuals with at least one tooth in the Ramfjord teeth with a probing depth (PD) between 3 mm and 5 mm. Individuals with bleeding on probing (BOP) in 10% or more of the sites in the Ramfjord teeth. Individuals exhibiting symptoms of gingivitis or mild periodontitis. Individuals with 20 or more natural teeth (excluding roots, implants, and impacted teeth, but including crowned teeth).
Exclusion criteria
Exclusion criteria: Individuals with clinically significant cardiovascular, immune, infectious, or neoplastic diseases. Individuals with uncontrolled hypertension (=160/100 mmHg, measured after 10 minutes of rest). Individuals with uncontrolled diabetes (fasting blood glucose =180 mg/dL or those who have started new medication for diabetes within the last 3 months). Individuals with mental disorders such as schizophrenia, depression, drug addiction, or alcohol dependence. Individuals with a history of bleeding disorders or diseases, or those taking antiplatelet or anticoagulant medications for prevention. Individuals diagnosed with cancer within the past 5 years. Individuals who have taken medications that can affect periodontal status (e.g., phenytoin, CCBs, cyclosporine, coumadin, NSAIDs, aspirin) for more than 5 consecutive days within the past month. Individuals who have taken antibiotics or adjunctive treatments for periodontal disease within the past month. Pregnant women and women planning to become pregnant. Breastfeeding women. Women within 6 months postpartum. Heavy smokers (average of 25 or more cigarettes per day). Individuals who consume excessive alcohol (men: more than 4 drinks per day or 15 drinks per week; women: more than 3 drinks per day or 8 drinks per week; Ministry of Health and Welfare standards: 1 standard drink = 7 g alcohol = 50 mL soju = 200 mL beer). Individuals with allergies or adverse reactions to the test product. Individuals who have taken probiotics other than the test product from 1 month before the start of the study until the end of the study. Individuals who have participated in another clinical trial within the past month. Individuals deemed unsuitable for participation in the study by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing depth and gingival index | — |
Secondary
| Measure | Time frame |
|---|---|
| Antiinflammatory, antibacteriual indicators and clinical parameters | — |
Countries
Korea, Republic of
Contacts
Public ContactMU YEOL CHO
Apple Tree Medical Foundation
Outcome results
None listed