Comparison of rocuronium-induced withdrawal movement (RIWM) following administration of remimazolam or propofol during induction of general anesthesia in elderly patients and analysis of the effect of lidocaine pretreatment

Comparison of rocuronium-induced withdrawal movement (RIWM) following administration of remimazolam or propofol during induction of general anesthesia in elderly patients and analysis of the effect of lidocaine pretreatment: a randomized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0009730

Enrollment

177

Registered

2024-08-26

Start date

2024-09-02

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In Group P, lidocaine 40mg IV + propofol 1mg/kg IV In Group R, normal saline 2cc IV + remimazolam 0.1mg/kg IV In Group LR, lidocaine 40mg IV + remimazolam 0.1mg/kg IV

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Elderly patients, aged 65 years or older, belongs to ASA class 1 to 3 and undergoing surgery under general anesthesia

Exclusion criteria

Exclusion criteria: - Under the age of 65 - BMI 35 or higher - ASA class 4 or above - Scheduled for emergency surgery requiring rapid sequence induction/intubation - Systemic or peripheral vascular disease - Symptoms of neurological deficits such as sensory deterioration and paralysis - Patients on opioid, anticonvulsant, antidepressant medications - Patients received analgesics or sedatives prior to induction of anesthesia on the day of surgery - History of hypersensitivity or serious side effects to drugs related to this study (Benzodiazepine including Remimazolam, Propofol, Lidocaine, and Rocuronium) - Those who refused to participate in this study

Design outcomes

Primary

Measure	Time frame
Incidence of Rocuronium-induced withdrawal movement(RIWM)	—

Secondary

Measure	Time frame
Percentage of the patients in each grade evaluated according to the RIWM scale;Complication events related to RIWM	—

Countries

Korea, Republic of

Contacts

Public ContactJe Jin Lee

Chung-Ang Univerisity Hospital

jjlee0222@cauhs.or.kr+82-2-6299-2579

Outcome results