AI-Enhanced Restoration of Brain PET/CT Images with Reduced Radiotracer Injection Doses

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0009640

Enrollment

Registered

2024-07-11

Start date

2024-09-02

Completion date

Unknown

Last updated

2024-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Radiation : In this study, 30 patients scheduled to take Brain Amyloid PET/CT at Severance Hospital were administered F18-florbetaben (FBB) or F18-flutemetamol (FMM) intravenously in 150 MBq. Brain Am

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 60 and older, both male and female. 2. Capable of communicating in Korean and sufficiently understanding and consenting to the purpose and process of the research. 3. Patients who, in the judgment of the examiner, have adequate vision, hearing, language ability, motor function, and comprehension to follow the testing procedures (use of aids such as glasses, hearing aids, etc., is allowed). 4. Patients with the cognitive ability to make voluntary decisions about participating in the research.

Exclusion criteria

Exclusion criteria: 1. Individuals suspected of having other causes of cognitive impairment such as neurosyphilis, hypo/hyper-thyroidism, metabolic encephalopathy, brain tumor, acute cerebral hemorrhage, acute cerebral infarction, Wernicke’s encephalopathy, based on hematologic tests and brain magnetic resonance imaging conducted within the last 6 months. 2. Patients without brain magnetic resonance imaging. 3. Employees directly involved in this clinical study or their immediate family members for whom voluntary participation is deemed difficult.

Design outcomes

Primary

Measure	Time frame
The statistical difference in Standardized Uptake Value Ratio (SUVR) between images acquired with reduced radiotracer injection dose and those acquired with the original count.	—

Secondary

Measure	Time frame
The image parameters (PSNR, SSIM, NRMSE) and visual analysis between images acquired with reduced radiotracer injection dose and those acquired with the original count.	—

Countries

Korea, Republic of

Contacts

Public ContactCHAEWON YU

Yonsei University Health System, Severance Hospital

chaewon3576@yuhs.ac+82-2-2228-4850

Outcome results