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Development of a noninvasive PTSD game therapy that induces forgetting of specific memories: a proof-of-concept study

Development of a noninvasive PTSD game therapy that induces forgetting of specific memories: a proof-of-concept study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0009516
Enrollment
150
Registered
2024-06-10
Start date
2023-12-05
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : After studying 36 pictures, subjects play a simple game on a computer screen. Half of the 36 previously studied pictures, 18, are shown on screen during the game. Of the 18 pictures s

Sponsors

Yonsei University Health System, Severance Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Undergraduate/graduate students/graduates of Yonsei University with physical age between 19 and 29 years old 2. Corrected visual acuity binocular average of 0.5 or better - No health problems 3. Speaks Korean 4. Those who voluntarily decided to participate and agreed in writing to follow the precautions

Exclusion criteria

Exclusion criteria: i. Too long or too short feedback cycle time during the learning phase (judged as an outlier if it does not fall within the IQR for the distribution of all subjects) ii. If wearing the EEG device takes longer than 10 minutes, they will be excluded from the EEG analysis. Also, subjects with poor EEG data measurement and recording will not be eligible for EEG segmentation.

Design outcomes

Primary

MeasureTime frame
1.Demonstrate that the memory accuracy for the experimental group, where the therapeutic intervention occurred, is lower than the memory accuracy for the control group (t-test, p<0.05).

Secondary

MeasureTime frame
1. Compare the memory accuracy of the consciously presented stimulus group and the unconsciously presented stimulus group to the control group, respectively, to verify that the memory weakening effect is valid even when the stimulus is presented non-invasively during unconsciousness. (t-test, p<0.05);1. Observe the persistence of the memory-weakening effect of the game over time by comparing the accuracy of Test1, Test2, and Test 3 (pairwise t-test, p<0.05).;1. Demonstrate that there is a significant difference in EEG between the learning phase before the game, the forward phase during the game, and the reverse phase. a. There is a difference in EEG between Learning vs. game_forward vs. game_reverse. (ANOVA, p<0.05) b. there is a significant change in EEG pattern between forward vs. reverse. (t-test, p<0.05) c. If the EEG change pattern of reverse is confirmed, compare reverse_con and reverse_uncon. (t-test, p<0.05);1. Demonstrate that there is a difference in the memory impairment effect of the game for images with positive emotional values and images with negative emotional values. (t-test, p<0.05)

Countries

Korea, Republic of

Contacts

Public ContactDawon Suh

Yonsei University

daawonsuh@gmail.com+82-2-216-3284

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026