None listed
Conditions
Interventions
Drug : Group 1. Administration of trial drug and 3 hours standing: Extinction past 3 hours after fear memory reactivation. Oral administration of a Promag Tablet 500mg (Magnesium Valproate) one time 3
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Participants provided with an explanation of the study and written consent. - Participants with uncorrected visual acuity of -8.0 to -2.0 diopters (no restrictions for corrected vision with glasses or lenses). - Participants not currently having administered any treatment medication and in physical health.
Exclusion criteria
Exclusion criteria: - Carefully considered group of Biolamin Tablet: patients currently taking L-dopa, patients with hyperoxaluria, or pregnant or lactating women. - Individuals with hypersensitivity to polyvitamin (with vitamine B1, B2, B6, B12, C, or E) - Individulas not classified as healthy subjects through clinical examination. - Individuals with organic brain damage or a history of head and neck trauma. - Patients currently undergoing psychiatric treatment or with a psychiatric history. - Individuals anticipating surgery or procedures which could interfere the study procedures. - Carefully considered and contraindicated group of Promag Tablet: patients with liver disease or impairment, renal failure or low protein levels, blood clotting disorders or low platelet count, a history of bone marrow damage or potential patients, or currently pregnant or potentially pregnant women. - Individuals with a history of adverse reactions to valproate. - Individuals with difficulty in oral mication intake. - Researchers directly involved in the present clinical study, researchers' families, employees of the research institution, and their families.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physiological responses including skin conductance response, electrocardiogram, respiration, and heart rate for each threat condition of stimuli and group;EEG (electroencephalogram) responses for each threat condition of stimuli and group | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective rating scores toward stimuli including risk assessment, valence, arousal, fear evaluation for each threat condition of the stimuli and group | — |
Countries
Korea, Republic of
Contacts
Public ContactMinhee Kim
Seoul National University Hospital
Outcome results
None listed