None listed
Conditions
Interventions
Drug : For the treatment group: Dexamethasone will be administered.
After randomization, patients in the treatment group will receive two doses of dexamethasone within 1 hour before surgery and 12 hou
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Adults aged 19 years and above (2) Patients diagnosed with neurofibroma or meningioma within the thoracic spinal cord (3) Patients capable of walking with a muscle strength of 3 or higher on the Medical Research Council (MRC) scale for lower limbs (4) Patients willing to participate in the study, adhere to treatment and procedures, and visit the hospital for all follow-up evaluations (5) Patients who have received explanations regarding the purpose, methods, and effects of the study and have voluntarily signed the informed consent form
Exclusion criteria
Exclusion criteria: (1) Patients who are either under 18 years of age or 66 years of age and older (2) Patients deemed by the investigator to be ineligible for spinal surgery under general anesthesia due to significant cardiovascular, pulmonary, hepatic, or renal dysfunction (3) Patients with diabetes mellitus (4) Patients with gastrointestinal disorders including gastritis and gastric ulcers (5) Patients with hypersensitivity reactions or adverse effects to steroids (6) Patients with infections in joint spaces, bursae, tendon sheaths, or around tendons (7) Patients receiving live bacterial vaccines (8) Patients with herpes simplex, herpes zoster, or chickenpox (9) Patients with infections where effective antimicrobial therapy is not available or systemic fungal infections (10) Patients receiving immunosuppressive therapy (11) Patients requiring reoperation due to recurrence of existing tumors (12) Patients diagnosed with neurofibromatosis (13) Patients with neurofibromas showing a dumbbell tumor pattern invading the neural foramina (14) Pregnant or lactating women (15) Patients with cognitive impairment making communication with medical staff and completion of surveys difficult
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Neurological evaluation of patients: mJOA (modified Japanese orthopedic association) score for thoracic myelopathy, Modified McCormick scale, ASIA scale (American Spinal Injury Association) ;Assessment of pain severity in patients: Pain DETECT Questionnaire, SF-MPQ (Short-form McGill Pain Questionnaire), LANSS (Leeds Assessment of Neuropathic Symptoms and Signs) pain scale;Assessment of quality of life in patients: EQ-5D (EuroQol-5Dimention), SF-36 (Short Form-36);Evaluation of activities of daily living in patients: SCIM III (Spinal Cord Independence Measure III);Complete resection of tumor post-surgery through magnetic resonance imaging (MRI) scans;Presence of spinal cord signal change through magnetic resonance imaging (MRI) scans;Adverse event | — |
Primary
| Measure | Time frame |
|---|---|
| Assessment of pain severity in patients using the Korean Neuropathic Pain Questionnaire (KNPQ) | — |
Countries
Korea, Republic of
Contacts
Public ContactYunJung Kim
Asan Medical Center
Outcome results
None listed