Randomized study to compare individualized positive end-expiratory pressure and fixed positive end-expiratory pressure in patients receiving mechanical ventilation in the prone position

Individualized versus fixed positive end-expiratory pressure during mechanical ventilation in the prone position: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0009405

Enrollment

Registered

2024-05-07

Start date

2024-04-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : In the individualized group, the recruitment manuever is performed after taking the prone position. Recruitment manuever is performed in volume-controlled ventilation mode with a r

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A. Adult patients aged 19 years or older undergoing surgery in the prone position with an estimated operating time of 60 minutes or more. B. American Society of Anesthesiologists physical status classification (ASA physical status classification) grade 1-2

Exclusion criteria

Exclusion criteria: A. Patients who did not consent to the study B. American Society of Anesthesiologists physical status classification (ASA physical status classification) grade 3-4 C. Patients requiring mechanical ventilation after surgery D. Patients with contraindications to positive end-expiratory pressure (pneumothorax, large bullae, hypovolemic shock, etc.) E. Patients deemed unsuitable for this clinical study according to the opinion of the researcher or research staff

Design outcomes

Primary

Measure	Time frame
Lung ultrasound score	—

Secondary

Measure	Time frame
Lung ultrasound score;respiratory variable (PaO2, PaO2:FiO2 ratio, driving pressure, static lung compliance, peak inspiratory pressure, plateau pressure);Total amount of fluid and transfusion;Types and dosages of vasoactive drugs;Incidence of hypoxemia (SpO2<92%);Incidence of pulmonary complications (hypoxemia (SpO2<92%), oxygen therapy within 2 days after surgery, mechanical ventilation for more than 24 hours, re-intubation, atelectasis confirmed by imaging, pneumonia, ARDS, postoperative acute lung injury, pleural effusion);Incidence of pulmonary complications (Dyspnea, pneumonia, respiratory-related readmission, etc.)	—

Measure

Time frame

Lung ultrasound score;respiratory variable (PaO2, PaO2:FiO2 ratio, driving pressure, static lung compliance, peak inspiratory pressure, plateau pressure);Total amount of fluid and transfusion;Types and dosages of vasoactive drugs;Incidence of hypoxemia (SpO2<92%);Incidence of pulmonary complications (hypoxemia (SpO2<92%), oxygen therapy within 2 days after surgery, mechanical ventilation for more than 24 hours, re-intubation, atelectasis confirmed by imaging, pneumonia, ARDS, postoperative acute lung injury, pleural effusion);Incidence of pulmonary complications (Dyspnea, pneumonia, respiratory-related readmission, etc.)

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Countries

Korea, Republic of

Contacts

Public ContactJinyoung Bae

Ajou University Hospital

baejy88@gmail.com+82-31-219-6433

Outcome results