A Comparative Study of Two Different Types of Dexamethasone for Pain Management After Knee Joint Replacement Surgery

Clinical trial evaluating the clinical efficacy of dexamethasone sodium phosphate and dexamethasone palmitate for pain management before and after surgery for knee joint arthroplasty_ randomized, double-blind, clinical study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0009362

Enrollment

114

Registered

2024-04-23

Start date

2024-04-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Experimental and Control Group Allocation: Patients will be assigned sequentially according to a pre-determined randomization table prior to the start of the study, utilizing blocked randomizat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients diagnosed with primary osteoarthritis of the hip joint who have received symptomatic treatment (medication, physical therapy) but have not achieved adequate pain control and are scheduled to undergo hip joint replacement surgery at the hospital, who understand the research content and agree to participate in the study.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: Age below 60 or above 80 years. Patients undergoing revision hip replacement surgery. Joint arthritis other than primary osteoarthritis (e.g., rheumatoid arthritis, psoriatic arthritis, gouty arthritis, lupus arthritis, post-traumatic arthritis, etc.). Hemoglobin level exceeding 8% before surgery. Surgery performed under spinal anesthesia rather than general anesthesia. Concurrent surgical procedures other than hip joint replacement during surgery. Use of steroids due to the patient's underlying condition before surgery (e.g., patients undergoing steroid inhaler therapy, patients receiving steroid replacement therapy due to adrenal insufficiency, etc.). Use of self-administered pain control devices after surgery. Administration of steroid injections within 3 months before surgery (intravenous, intra-articular, etc.). Use of steroids for purposes other than the study objectives during hospitalization after surgery (e.g., spinal or joint injections). Occurrence of postoperative medical emergencies requiring additional treatment (e.g., stroke, acute coronary syndrome, acute respiratory distress syndrome). Allergy to dexamethasone sodium phosphate or dexamethasone palmitate. Hypersensitivity or allergy to soybean oil. Patients with hypersensitivity to soybeans or peanuts.

Design outcomes

Primary

Measure	Time frame
Postoperative pain, severity of postoperative nausea and vomiting (NRS), and usage of rescue medications.	—

Secondary

Measure	Time frame
Postoperative blood sugar elevation and surgical site infection.	—

Countries

Korea, Republic of

Contacts

Public ContactHyung Jun Park

Korea University Ansan Hospital

ppakyung@hotmail.com+82-31-412-5049

Outcome results