None listed
Conditions
Interventions
Biological/Vaccine, Stem Cell : Multiploe drilling
1. ADSVF one time 3 ml femoral head injection
2. Normal saline one time 3 ml femoral head injection
Sponsors
Hyundae Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Subjects with non-traumatic femoral head avascular necrosis who consent to this study - Subjects who have not received other treatments such as core decompression and multiple trepanation for avascular necrosis of the femoral head in the relevant area - Before the femoral head collapses or when the depth of collapse is less than 2 mm - Subjects with more than 30% necrosis of the femoral head
Exclusion criteria
Exclusion criteria: - Subjects with a depth of femoral head collapse of 2 mm or more - Subjects with more than 30% necrosis of the femoral head - Subjects who have received treatment of core decompression and multiple trepanation for avascular necrosis of the femoral head in the relevant area - Subjects taking osteoporosis treatments such as bisphosphonates or parathyroid hormones - Subjects who are taking immunosuppressants or cytotoxic agents or who need to take them during the test period - Subjects who must continuously take corticosteroids for treatment purposes - Subjects who are unable to undergo MRI (magnetic resonance imaging) due to artificial pacemakers, metallic hip joints, prosthetics, etc. - Subjects who are pregnant or breastfeeding - Subjects currently suffering from infectious diseases including HIV and hepatitis - Subjects with serious diseases that may affect this clinical trial: cardiovascular disease, tumor, kidney disease, endocrine disease such as decreased bone metabolism, increased bone metabolism and thyroid disease, autoimmune disease, etc. - Subjects who participated in another clinical trial within 3 months of participating in this clinical trial - In other cases where the researcher determines that participation in this study is inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion rate to Total hip treplacement | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To find out whether osteonecrotic lesions in the femoral head change and decrease in size or disappear. 2. Harris Hip Score , The Western Ontario and McMaster Universities Arthritis Index, University of California Los Angeles Score | — |
Countries
Korea, Republic of
Contacts
Public ContactKang Sup Yoon
Hyundae Hospital
Outcome results
None listed