None listed
Conditions
Interventions
Dietary Supplement : Experimental group: Subjects will take one capsule of L. plantarum KF511 orally one daily for 12 weeks.
Control group: Subjects will take one capsule of placebo orally one daily f
Sponsors
Jeonbuk National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 19 to 80 years 2) A person who has two or more symptoms of persistent respiratory symptoms (cough, sputum, dyspnoea or chest pain) for at least one month 3) Voluntary agreement to participate in the clinical trials and provision of informed consent
Exclusion criteria
Exclusion criteria: 1) Smoker 2) Forced expiratory volume in the first second/ Forced vital capacity (FEV1/FVC) ratio (post-bronchodilator) 3 fold of normal range or serum creatinine > 2.0 mg/dl 12) Pregnant, planning to become pregnant, or breast-feeding 13) Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the studya n
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function test;St. George’s respiratory questionnaire (SGRQ);modified Medical research council dyspnea scale;WBC count and WBC differential count;Cytokines (IL-6, IFN-?, TNF-a, CXCL1, CXCL2);Matrix metalloproteinase-9 | — |
Primary
| Measure | Time frame |
|---|---|
| CAT (COPD assessment test);BCSS (Breathless, cough, and sputum scale) | — |
Countries
Korea, Republic of
Contacts
Public ContactMi-Ra Oh
Jeonbuk National University Hospital
Outcome results
None listed