Effect of a modified goal-directed fluid therapy on postoperative complications in patients undergoing brain tumor surgery

Effect of a modified goal-directed fluid therapy on postoperative complications in patients undergoing brain tumor surgery: a randomized assignment trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0009241

Enrollment

210

Registered

2024-03-12

Start date

2024-01-25

Completion date

Unknown

Last updated

2024-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others(fluid management) : Patients are randomized into two groups: those who receive more restrictive goal-oriented fluid therapy, in which fluid is injected only when stroke volume variation is high

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients 18 years of age or older undergoing brain tumor removal under general anesthesia

Exclusion criteria

Exclusion criteria: Patients who do not agree to the study Patients with severe cardiopulmonary or renal disease Patients who are unable to give informed consent due to a decreased level of consciousness

Design outcomes

Primary

Measure	Time frame
composite postoperative complication	—

Secondary

Measure	Time frame
pH, lactate, paCO2, PaO2/FiO2, Hct, BUN, creatinine, eGFR, bilirubin, AST, ALT;Invasive systolic/diastolic arterial pressure, mean arterial pressure, pulse rate, invasive central venous pressure, cardiac output, cardiac index, stroke volume variation, stroke volume index, peripheral oxygen saturation;Hypotensiove episode count, duration;Ephedrine, phenylephrine, norepinephrine, propofol, remifentanil dose, infused plasma solution A amount, infused pRBC amount, estimated blood loss, urine output;neurologic monitoring abnormalities;neuron-specific enolase;anesthesia time, surgery time;in hospital mortality;Total length of stay, ICU length of stay;Time to extubation;Time to recovery of bowel function;Modified Rankin Scale	—

Measure

Time frame

pH, lactate, paCO2, PaO2/FiO2, Hct, BUN, creatinine, eGFR, bilirubin, AST, ALT;Invasive systolic/diastolic arterial pressure, mean arterial pressure, pulse rate, invasive central venous pressure, cardiac output, cardiac index, stroke volume variation, stroke volume index, peripheral oxygen saturation;Hypotensiove episode count, duration;Ephedrine, phenylephrine, norepinephrine, propofol, remifentanil dose, infused plasma solution A amount, infused pRBC amount, estimated blood loss, urine output;neurologic monitoring abnormalities;neuron-specific enolase;anesthesia time, surgery time;in hospital mortality;Total length of stay, ICU length of stay;Time to extubation;Time to recovery of bowel function;Modified Rankin Scale

—

Countries

Korea, Republic of

Contacts

Public ContactKyung Won Shin

Seoul National University Hospital

skwskw1@naver.com+82-2-2072-0586

Outcome results