None listed
Conditions
Interventions
Others : This is a program that provides exercise intervention using a mobile application and oral nutritional supplement drinks for 12 weeks for patients receiving chemotherapy.
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age 19 or older 2) Patients with histologically confirmed solid cancer 3) Planned or receiving palliative chemotherapy or neoadjuvant/adjuvant chemotherapy using two or more cytotoxic chemotherapy agents 4) ECOG performance status 0-2 5) If a basal abdominal CT (contrast CT must include the portal phase) that can confirm sarcopenia was taken within 4 weeks of participating in the study. 6) Class I or class II sarcopenia with skeletal muscle index (=skeletal muscle area / BMI) T-score less than -1.0 measured by CT 7) Life expectancy of more than 3 months 8) Patients who can understand the research subject consent document and are willing to sign it
Exclusion criteria
Exclusion criteria: 1) Cases where there is a high risk of injury or fall during exercise intervention, such as bone metastasis, peripheral neuropathy, brain metastasis, etc. 2) Cases where it is difficult to follow the exercise intervention of the mobile application due to cognitive decline, illiteracy, or severe hearing and vision impairment. 3) If you do not have a smartphone 4) Cases where protein intake is limited due to decreased renal function (eGFR <50mL/min/1.73m2) 5) When the researcher determines that exercise and nutritional intervention are not best for the patient due to other clinical conditions. 6) Over 80 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SMI (skeletal muscle index) T-score assessed by CT | — |
Secondary
| Measure | Time frame |
|---|---|
| Myosteatosis index assessed by CT (NAMA/TAMA index T-score) *NAMA (normal-attenuation muscle area), TAMA (total abdominal muscle area);Skeletal muscle mass, fat mass, lean body mass (kg/m2) evaluated by BIA (Bioelectrical Impedance Analysis);Body Mass Index (kg/m2) , Ht, weight, waist circumference;Nutritional assessment using MNA-SF (Mini Nutritional Assessment-Short Form);Exercise evaluation using SPBB (short physical performance battery);Hand grip strength (kg) ;(health-related quality of life; EORTC-QLQ-C30);Compliance to exercise and nutrition interventions (%);Progression-free survival (calculated separately for metastatic and non-metastatic cancer);Overall survival (calculated separately for metastatic and non-metastatic cancer);Blood test results (CRP, LD, CBC, t-chol, albumin); Incidence, nature and severity of adverse events with severity (Safety profile) - Common Terminology Criteria for Adverse Events (CTCAE) v5.0 | — |
Countries
Korea, Republic of
Contacts
Public ContactSunyoung Kim
Asan Medical Center
Outcome results
None listed