None listed
Conditions
Interventions
Drug : - Active comparator group (Maxigesic group, group M)
Maxigesic 1 ampule (100 ml, 1st dose) & NSS 100 ml (placebo, blinded) administered simultaneously 15 minutes before surgery completion.
Sub
Sponsors
Chungnam National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Elective laparoscopic gastrectomy 2. American Society of Anesthesiologists Physical Status Classification 1-3 3. Age range: 20-80 years 4. BMI (Body Mass Index) range: 18.5-35 kg/m2 5. Patients scheduled for the use of patient-controlled analgesia device
Exclusion criteria
Exclusion criteria: 1. Wedge resection 2. Previous non-minor abdominal surgeries (examples of minor surgery: appendectomy, cholecystectomy, hernia repair, etc.) 3. Combined surgery 4. Known allergy or asthma reaction to the study drugs 5. Regular use of narcotic analgesics for more than 3 months before surgery 6. Concurrent use or requirement of analgesics due to ongoing pain 7. Impaired renal function (eGFR < 30 mL/min/1.73 m2) 8. Impaired liver function (cirrhosis, acute hepatitis, preoperative AST or ALT levels greater than 100 [more than twice the normal range]) 9. Pregnancy or breastfeeding 10. Active peptic ulcer disease 11. Closed-angle glaucoma 12. In cases of cognitive impairment and communication limitations making patient-controlled analgesia (PCA) use and pain assessment difficult 13. If planned postoperative pain control does not align with this study (e.g., if a different pain control method such as nerve block is planned)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption during postoperative 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption during postoperative 24 hours;Immediate postoperative pain (NRS, post-anesthesia care unit) ;postoperative day 1 morning pain (maximum/ minimum NRS);postoperative day 2 morning pain (maximum/ minimum NRS);postoperative day 1 QOR 15;postoperative day 2 QOR 15;use of rescue antiemetics ;use of rescue analgesics | — |
Countries
Korea, Republic of
Contacts
Public ContactChahyun Oh
Chungnam National University Hospital
Outcome results
None listed