None listed
Conditions
Interventions
Medical Device, Others : Transcranial magnetism with cognitive function training is used once a day, 5 days a week and 6 weeks (a total of 30 times). Three brain regions are treated per day, for which
Sponsors
AT&C
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who started drug treatment with an acetylcholinesterase inhibitor at least 2 months before participating in the clinical trial and can participate in the clinical trial without changing the dose during the trial period. 2. Male or female age 60-85 years. 3. Patients diagnosed with mild stage of Alzheimer's Disease, according to the NIA-AA (2011) diagnosis. 4. MMSE score 21 to 26. 5. CDR 1 or GDS 3. 6. Patients with a positive amyloid PET-CT. 7. Patients who are judged physically capable of clinical trials based on medical records and examinations. 8. Patient whose legal representative agrees to participate in a clinical trial and who can visit for the next observation with a guardian. 9. Patients who agreed to participate in all 24-week clinical trials. 10. Patients with normal ability to see and hear letters. 11. Patients who speak Korean as their mother tongue.
Exclusion criteria
Exclusion criteria: 1. Patients with a central nervous system disease that can affect cognitive function and is likely to be another cause of cognitive decline, or a type of dementia other than Alzheimer's, is suspected. 2. Patients who have been unconscious due to brain surgery or concussion, or who have signs or symptoms of cranial pressure elevation on neurologic examination. 3. History of Epileptic Seizures or Epilepsy. 4. Patients with a history of drug abuse, including alcohol, in the past 5 years from the time of screening. 5. Patients with schizophrenia, schizoaffective disorder, bipolar disorder, current major depressive episode, psychosis, panic, post-traumatic stress, severe anxiety, mental retardation, DSM-V disorder. 6. Patients with abnormal vitamin B12, folic acid deficiency, or thyroid stimulating hormone (TSH) test results that were considered by the investigator to affect or are caused by the severity of dementia. 7. Patients with metal implants in the head, (i.e. cochlear implants, implanted brain stimulators and neurostimulators, aneurysm clips) with the exception of metal implants. 8. Cardiac pacemakers. 9. Implanted medication pumps. 10. Intracardiac lines. 11. Patients who are currently taking medications that lower the convulsive seizure threshold. 12. Significant heart disease. 13. Significant renal disease, Significant hepatic disease. 14. Contraindication for performing MRI scanning. 15. Contraindication for performing amyloid PET-CT scanning. 16. Patients who do not consent to TMS treatment and participation in this clinical trial. 17. Patients who participated in other clinical trials 3 months before participating in this clinical trial. 18. Patients with a history of TMS treatment within the last 2 years before participating in this clinical trial. 19. Patients judged by the investigator to be unsuitable for participation in clinical trials for other reasons. 20. Patients with a history of malignant tumors within the last 5 years. - Participation is possible if more than 5 years have elapsed without recurrence after the decision to be cured (The point of complete removal of the tumor through surgery or the end of chemotherapy, etc.). 21. Patients who need to take medications suggested in concomitantly contraindicated drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale-Cognitive Subscale score | — |
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale-Cognitive Subscale score and Korean-Mini Mental State Examination, 2nd Edition, Clinical Dementia Rating, Global Deterioration Scale, Clinical Global Impression of Change, Korean Instrumental Activities of Daily Living;Alzheimer's Disease Assessment Scale-Cognitive Subscale score and Korean-Mini Mental State Examination, 2nd Edition, Clinical Dementia Rating, Global Deterioration Scale, Clinical Global Impression of Change, Korean Instrumental Activities of Daily Living;Alzheimer's Disease Assessment Scale-Cognitive Subscale score and Korean-Mini Mental State Examination, 2nd Edition, Clinical Dementia Rating, Global Deterioration Scale, Clinical Global Impression of Change, Korean Instrumental Activities of Daily Living | — |
Countries
Korea, Republic of
Contacts
Public ContactJinwoo Shin
AT&C
Outcome results
None listed