Effects of resistance exercise and nitrate on middle-aged women with sarcopenia

Effects of Resistance Training and Nitrate Intake for 12 Weeks on Thigh Muscle Function, Sarcopenia, and Osteoarthritis Symptoms in Middle-Aged Women with Sarcopenia Who Underwent Osteochondral Regeneration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0008830

Enrollment

Registered

2023-09-25

Start date

2023-09-18

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Dietary Supplement, Others(Resistance exercise) : The resistance exercise intervention program will be a modified and supplemented method of Noyes' (2016) rehabilitation program after cartilage surger

James White Drinks, Ipswich, United Kingdom) containing a high concentration of nitrate and 70 mL of placebo without nitrate ( 0.04mmol NO3-, James White Drinks, Ipswich, United Kingdom) will be provi

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: According to the AWGS criteria, the subjects of this study had a hand grip strength of 18 kg or less or a score of 9 or less on the Short Physical Performance Battery (SPPB) and a skeletal muscle index (SMI) of <5.7. Includes sarcopenic middle-aged women aged 45-65 with a weight of kg/m2 who will undergo mesenchymal stem cell transplantation within one month for the treatment of grade 4 cartilage damage according to the International Cartilage Repair Society (ICRS) criteria. I plan to do it.

Exclusion criteria

Exclusion criteria: Exclusion criteria include patients with severe arthritis of stage 4 based on the Kellgren-Lawrence classification, patients with a history of acute coronary syndrome or cardiovascular disease, and body mass index ( Patients with body mass index of 30kg/m2 or more, patients with systolic blood pressure of less than 115mmHg or more than 160mmHg, patients with diastolic blood pressure of less than 75mmHg or more than 100mmHg, and anti-hypertensive drugs. It will be set as patients using medication (Rogerson et al., 2022)

Design outcomes

Primary

Measure	Time frame
Cross-sectional area of thigh muscles;Quadriceps strength	—

Secondary

Measure	Time frame
physical performance assessment;Skeletal Muscle Index;Grip strength;Osteoarthritis symptoms	—

Countries

Korea, Republic of

Contacts

Public ContactHansoo Park

Korea National Sport University

hansoo85@hanmail.net+82-2-428-3347

Outcome results