Incidence of postoperative nausea and vomiting after remimazolam or propofol anesthesia

Incidence of postoperative nausea and vomiting after remimazolam or propofol based total intravenous anesthesia for breast surgery: A randomized controlled non-inferiority trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0008825

Enrollment

Registered

2023-09-25

Start date

2023-08-30

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In both groups, target controlled infusion of Remifentanil was started at a plasma target concentration of 4 ng/ml. a. Propofol group: To induce anesthesia, intravenous infusion of propofol is

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Non-smoking adult female patients aged 19 years or older undergoing elective partial mastectomy under general anesthesia at Yonsei Cancer Center

Exclusion criteria

Exclusion criteria: 1. Patients with a history of hypersensitivity or allergy to propofol or remimazolam 2. Patients who are contraindicated for propofol total intravenous anesthesia 3. Patients who are contraindicated for Remimazolam anesthesia 4. Pregnant women, patients with ASA PS-III abnormality

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea within 24 hours after completion of surgery	—

Secondary

Measure	Time frame
Incidence of postoperative vomiting within 24 hours after completion of surgery;Severity of postoperative nausea within 24 hours after completion of surgery;Dose of rescue analgesics administered up to 24 hours after surgery;Dose of rescue antiemetics administered up to 24 hours after surgery;Pain score in the recovery room immediately after surgery;Satisfaction with pain control after postoperative 24 hours;Incidence of intraoperative hypotention	—

Measure

Time frame

Incidence of postoperative vomiting within 24 hours after completion of surgery;Severity of postoperative nausea within 24 hours after completion of surgery;Dose of rescue analgesics administered up to 24 hours after surgery;Dose of rescue antiemetics administered up to 24 hours after surgery;Pain score in the recovery room immediately after surgery;Satisfaction with pain control after postoperative 24 hours;Incidence of intraoperative hypotention

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Countries

Korea, Republic of

Contacts

Public ContactYoungwon Kim

Yonsei University Health System, Severance Hospital

youngwon.md@gmail.com+82-2-2224-1465

Outcome results