None listed
Conditions
Interventions
Dietary Supplement :
- Green-lipped mussel powder 1,000 mg/day(500 mg x 2 capsules)
- oral intake with water once a day after breakfast or dinner
- intake period: total 84 days(12 weeks)
- Maltodext
Sponsors
Pusan National University Korean Medicine Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult men and women between the ages of 40 and 75 2. Those with a knee joint pain score (Visual Analogue Scale (VAS)) of 3/10 or higher 3. Those who are grade 1 or 2 on the Kellgren & Lawrence grading scale through ‘Both Knee Joint AP/LAT’ 4. Those who have had a wash-out period of arthritis-related medicines or health functional foods for more than 4 weeks 5. Applicants who are capable of normal physical activity are subjects of this test and voluntarily agree in writing to the test consent form
Exclusion criteria
Exclusion criteria: 1. Those with a history of fracture within the last year 2. Those who are diagnosed with moderate arthritis and are accompanied by osteophytes around the joints, irregular joint surfaces, and subchondral bone cysts of the joints. 3. Those diagnosed with thyroid disease and currently receiving treatment 4. Those with kidney disease or serum creatinine level of 1.4 mg/dL or higher 5. Those with proteinuria of 2+ or more 6. Those with liver disease (excluding fatty liver) or AST or ALT of 100 IU/L or more 7. Patients with uncontrolled high blood pressure or heart diseases such as angina pectoris or myocardial infarction 8. Persons taking medication for psychiatric illness (excluding cases of intermittent medication due to sleep disorders) 9. Those who have taken any herbal medicine or herbal medicine within 2 months before the screening test 10. Those who received other investigational drugs within 4 weeks before the screening test 11. Persons who must continue to take drugs that are judged to have an effect on the results of human application tests 12. Those with a history of gastrointestinal resection (excluding the appendix) 13. Pregnant or lactating women 14. Alcohol abuse 15. Persons with hypersensitivity to the test food or its ingredients 16. Persons who may be uncooperative in this examination Or a person who the researcher determines is unable to proceed with the test. 17. A person who, at the discretion of the test director, has arthritis caused by a specific factor other than degenerative disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC questionnaire total score | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC questionnaire detailed item scores (pain, joint stiffness, physical function);Visual Analogue Scale;ESR(Erythrocyte Sedimentation Rate);CRP(C-reactive protein) density | — |
Countries
Korea, Republic of
Contacts
Public ContactHyejin Park
Pusan National University Korean Medicine Hospital
Outcome results
None listed