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Evaluation of drug concentration according to genotype and inflammation by cardiopulmonary bypass surgery

Evaluation of pharmacotherapy and drug metabolism according to genotype and inflammation response by cardiopulmonary bypass surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0008742
Enrollment
30
Registered
2023-08-25
Start date
2021-12-15
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Gachon University Gil Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patient who received open heart surgery in Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center 2) Adult aged 19 years or above 3) Patient who received heart surgery using cardiopulmonary bypass 4) Voluntarily signed and dated written informed consent after sufficient explanation about the full nature and purpose of the study 5) Patient has the ability and will to participate during study period.

Exclusion criteria

Exclusion criteria: 1) Patient who received renal replacement therapy 2) Patient who was on special diets or drugs that were known to modulate drug metabolizing enzymes or affect absorption, distribution, metabolism and excretion of drug 3) Patients judged not eligible for the study after reviewing the clinical laboratory results or other reasons by the investigator

Design outcomes

Primary

MeasureTime frame
Clearance of sufentanil

Secondary

MeasureTime frame
Concentration of sufentanil at steady state

Countries

Korea, Republic of

Contacts

Public ContactDongseong Shin

Gachon University Gil Medical Center

dsshin@gilhospital.com+82-32-460-9459

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026