None listed
Conditions
Interventions
None listed
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients diagnosed with reflux esophagitis by upper gastrointestinal endoscopy. Age: 40 to 80 years old
Exclusion criteria
Exclusion criteria: ? Helicobacter pylori positive patient ? Patients with drug allergies to fexuprazan or esomeprazole ? a patient with a history of gastrectomy or bowel resection ? Patients under 40 or over 80 years of age ? Patients with therapeutic history of antibiotics or gastric acid secretion inhibitors (proton pump inhibitors, histamine-2 receptor blockers, potassium competitive gastric acid secretion inhibitors) over the past 6 months ? Patients diagnosed with inflammatory bowel disease (cron disease, ulcerative colitis) or irritable bowel syndrome ? a patient on immunosuppressants ? Patients who are scheduled to receive oral or intravenous anticancer drugs ? a pregnant woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microbial diversity between PPI and PCAB(4weeks and 12 weeks, respectively): alpha and beta divertsity | — |
Secondary
| Measure | Time frame |
|---|---|
| functional analysis of changed gut microbiome using PICRUSt software, correlation between change of microbiome and dietary habit | — |
Countries
Korea, Republic of
Contacts
Public ContactLIM SUN GYO
Ajou University Hospital
Outcome results
None listed