None listed
Conditions
Interventions
None listed
Sponsors
Soon Chun Hyang University Hospital Seoul
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with liver cirrhosis above Child-Pugh score 7, with ascites 2) Age of 19-70 3) Patients who could be accessed to hepatic artery by catheterization 4) In case of women, negative results for pregnancy test and planning to conduct contraception 5) Patients who could follow the study guidelines 6) Patients who agree to the informed consent
Exclusion criteria
Exclusion criteria: 1) Patients who were diagnosed for solid cancer in 5 years 2) Patients who had transjugular intrahepatic portosystemic shunt 3) Patients who had significant alcohol consumption (Men 210g/week, Women 140g/week) in 3 months or hepatotoxic agents in 6 months 4) Patients with detection of hepatitis B virus or hepatitis C virus in the blood 5) In the screening timepoint, patient who had high dose steroid (prednisolone above 10mg/day for longer than 7 days), antibiotics for severe infection, or immunosuppressants 6) Paients who had significant traumatic history in 3 months 7) In the screening timepoint, patients who had been diagnosed for the disease below - Severe aplastic anemia - History of liver transplantation - Active autoimmune hepatitis - Active viral hepatitis - Acute alcohol associated hepatitis - Extrehepatic biliary stricture - Heart failure or respiratory failure - Severe renal insufficiency - Acute or chronic infection which require systemic therapy 8) Patients who had active portal vein thrombosis or hepatic vein thrombosis 9) Patients who are not able to had bone marrow aspiration due to bone marrow diesease 10) Pregnants or patient who are breastfeeding 11) Patients who are not able to follow the study guidelines 12) Patients who were subjects for the other clinical trials in 30 days 13) Patients who had cell therapy before 14) Patients who had complications which is judge by instructor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume of ascites evaluated by non-contrast abdomen CT | — |
Secondary
| Measure | Time frame |
|---|---|
| MR elastography;Fibrosis-4, FIB-4;Model for end state liver disease (MELD);Child-Pugh score;Decompensation events;Score of life quality;Serum AFP/CEA and stool occult blood test | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Chang
Soon Chun Hyang University
Outcome results
None listed