None listed
Conditions
Interventions
Drug : Patients using vasoconstrictors will be randomly assigned to the topical nitroglycerin group or the control group. Nitroglycerin ointment 0.5% (30mg) will be applied to the proximal 2cm of the
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (19 years or older) in surgical intensive care unit who are treated with vasopressors.
Exclusion criteria
Exclusion criteria: Patients under 18 years Patients who cannot provide voluntary consent due to impaired consciousness Pregnant or breastfeeding patients Patients with vascular diseases Patients with thrombosis or embolism in the relevant ulnar artery on ultrasound examination Patients with a history of hypersensitivity or adverse reactions to nitroglycerin Patients who have taken other nitrates within the past 24 hours Patients taking phosphodiesterase-5 inhibitors (such as sildenafil, vardenafil, tadalafil, etc.) Patients with headaches or dizziness Patients with glaucoma or increased intracranial pressure Patients with methemoglobinemia Patients with skin lesions at the application site
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Change (%)of diameter and area of radial artery and distal perfusion index, AUC of perfusion index, ischemic injury of distal finger, length of icu stay, and in-hospital mortality | — |
Primary
| Measure | Time frame |
|---|---|
| Distal peripheral perfusion index | — |
Countries
Korea, Republic of
Contacts
Public ContactLeerang Lim
Seoul National University Hospital
Outcome results
None listed