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A Prospective, Multi-center Clinical Study to Establish Multi-Cancer Early Detection Platform through the Analysis of Whole Genome Sequencing of Circulating DNA in Cancer Patients and Healthy Volunteers

A Prospective, Multi-center Clinical Study to Establish Multi-Cancer Early Detection Platform through the Analysis of Whole Genome Sequencing of Circulating DNA in Cancer Patients and Healthy Volunteers

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0008484
Enrollment
4000
Registered
2023-06-01
Start date
2022-10-13
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Yonsei University Health System, Severance Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: - Subjects prior to the start of treatment for stages 1 to 4 of various solid carcinomas or healthy adults who have scheduled a cancer medical examination - Men and women over 19 years of age - Subjects and healthy adults who agree to collect and analyze clinical information and human-derived materials for research purposes, and agree to store residual blood samples and use them for secondary research purposes - Subjects who can donate blood without harming their health - Subjects who understand and voluntarily agree to this study

Exclusion criteria

Exclusion criteria: - Subjects under the age of 19 - Vulnerable subjects with mental retardation or severe psychiatric conditions - Subjects who are unable to participate in the study due to other reasons as determined by the researcher - Subjects with a history of HIV, HTLV, and Syphilis infection - Subjects diagnosed with primary unknown cancer or multiple cancers - Subjects diagnosed with other malignant tumor within 5 years(except for non-melanoma skin cancer treated for cure, in-situ disease treated for cure, thyroid cancer, or intraepithelial carcinoma of the cervix)

Design outcomes

Primary

MeasureTime frame
Developing an analysis platform that can be used for early screening of some cancers

Secondary

MeasureTime frame
Establishing a whole-genome sequencing(circulating DNA in blood) and clinical information database from 1,500 cancer subjects and 500 healthy adults

Countries

Korea, Republic of

Contacts

Public ContactRyeo Choi

SEVERANCE HOSPITAL

rchoi@yuhs.ac+82-2-2228-8171

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026