None listed
Conditions
Interventions
Drug : Group1
-Gentamicin sulfate (80mg/2ml) 0.6ml + Normal Saline 0.4ml
1ml (concentration of gentamicin : 24mg/ml) intratympanic injection .
Group2
- Gentamicin sulfate (80mg/2ml) 0.6ml + Dexame
Sponsors
Yonsei University Health System, Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Definite Meniere’s disease -If there is no improvement in medication treatment for more than 3 months and there is more than 1 dizziness attack per month -The average hearing on the affected side is more than mild hearing loss (0.5, 1, 2, 3 kHz average airway hearing threshold > 25 dB on pure tone audiometry)
Exclusion criteria
Exclusion criteria: -When CNS-caused dizziness is suspected -Symptoms after head trauma -Past history of other otological diseases such as otitis media -Bilateral Meniere's disease -Taking steroids for an underlying disease -If the affected side is the better ear (when the average airway hearing threshold of the affected side is lower than the contralateral side on pure tone audiometry)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hearing difference between the two groups after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients who dropped out due to the need for additional treatment after treatment in both groups;Serial hearing change after treatment in both groups;Changes in vestibular function (caloric, vHIT) after treatment in both groups;Frequency of dizziness after treatment in both groups | — |
Countries
Korea, Republic of
Contacts
Public ContactSeong Hoon Bae
Yonsei University Health System, Severance Hospital
Outcome results
None listed