The effect of Volatile induction and maintenance of anesthesia(VIMA) versus Total intravenous anesthesia(TIVA) on the response of pro-inflammatory cytokine during perioperative period of sepsis and septic shock resulting from secondary peritonitis: Prospective study

The effect of Volatile induction and maintenance of anesthesia(VIMA) using Sevoflurane versus Total intravenous anesthesia(TIVA) using Propofol on the response of pro-inflammatory cytokine Interleukin-6 during perioperative period of sepsis and septic shock resulting from secondary peritonitis: Prospective study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0008354

Enrollment

Registered

2023-04-13

Start date

2022-10-31

Completion date

Unknown

Last updated

2023-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Group VIMA: Sevoflurane will be used both as induction agent and for maintenance of anesthesia. And, The patients will receive inhalation anesthesia with sevoflurane /O2/ air. Anesthesia will b

Hana Pharm Co., Ltd, Korea). For induction, the end tidal sevoflurane concentration will be kept at 0.5–2 vol%. When the bispectral index (BIS) ranges between 40 and 60, rocuronium (0.6 mg/kg) will be

a combination of propofol (Fresofol 2%TM, Fresenius Kabi Korea) and remifentanil will be used. Propofol will be administered intravenously with Target-Controlled Infusion (OrchestraTM BasePrimea, Fres

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The inclusion criteria includes age older than 18; American Society of Anesthesiologists physical status (ASA) score of 1 or 2; and sepsis or septic shock resulted from secondary peritonitis from suspected or proven colorectal origin needing for abnominal surgery. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. A change in baseline of the total SOFA score of 2 points or more represents organ dysfunction. Septic shock is defined as a subset of sepsis in which underlying circulatory and cellularmetabolism abnormalities are profound enough to substantially increase mortality. Septic shock can be identified with a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP65mmHg and having a serum lactate level >2 mmol/L (18mg/dL) despite adequate volume resuscitation.

Exclusion criteria

Exclusion criteria: The inclusion criteria includes age less than 18; American Society of Anesthesiologists physical status (ASA) score more than 3; sepsis or septic shock resulted from secondary peritonitis which in not proved to colorectal origin; sedation state for endotracheal intubation and mechanical ventilation before general anesthesia; need for sedation state for reintubation and mechanical ventilation within 24 hours after surgery and extubation due to deterioration; and pregnancy.

Design outcomes

Primary

Measure	Time frame
Interleukin-6	—

Secondary

Measure	Time frame
SOFA score, plasma levels of CRP, procalcitonin and lactic acid, vasopressor requirement, durations of mechanical ventilation, ICU length of stay, and 28-day mortality	—

Countries

Korea, Republic of

Contacts

Public ContactSehun Kim

Inje University Haeundae Paik Hospital

anesehunkim@naver.com+82-51-797-0478

Outcome results