Effects of Remimazolam on Intraoperative Blood Pressure Control in Interventional Cerebral Aneurysm Coil Embolization

Effects of Remimazolam on Intraoperative Blood Pressure Control in Interventional Cerebral Aneurysm Coil Embolization; A pilot study of a prospective randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0008343

Enrollment

Registered

2023-04-07

Start date

2023-03-27

Completion date

Unknown

Last updated

2023-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In the test group (group B), anesthesia is maintained with remimazolam after induction of anesthesia with remimazolam (trade name: byfavo). 1 vial of byfavo is dissolved in 50 mL of physiologic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients over age 19 undergoing elective cerebral aneurysm coil embolization at Korea University hospital under general anesthesia, who have agreed to terms.

Exclusion criteria

Exclusion criteria: Patients who have already been intubated and sedated before general anesthesia Patients without tracheal extubation after coil embolization Patients with hemodynamic instability, such as shock or coma Patients with hypersensitivity or specific reactions to narcotic drugs, including sevoflurane and remifentanil, and benzodiazepines Patients who are an absolute contraindication to the administration of remimazolam; Patients with acute narrow-angle glaucoma, patients with acute alcoholism with suppressed vital signs, patients with severe or acute respiratory failure, patients with genetic lactose intolerance such as galactose intolerance, patients with severe hypersensitivity to dextran 40 Patients with mental retardation or difficulties in reading Korean Subjects who are vulnerable to research (research participants who are vulnerable to coercion or undue influence, or those who lack decision-making ability; pregnant women, fetuses/newborns, minors, those who lack decision-making ability, students, staff, voluntary decision to participate due to surrounding environment susceptible to) Patients unable to continuously monitor arterial blood pressure through the radial artery

Design outcomes

Primary

Measure	Time frame
Intraoperative blood pressure	—

Secondary

Measure	Time frame
Intraoperative heart rate, vasopressor usage, mortality within 30 days POD, delirium 7days POD, AKI 7 days POD (according to KDIGO guideline)	—

Countries

Korea, Republic of

Contacts

Public ContactEunji Ko

Korea University Anam Hospital

froken_ko@naver.com+82-2-920-5632

Outcome results