Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol in patients undergoing short-duration gynecologic surgery under general anesthesia

Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol in patients undergoing short-duration gynecologic surgery under general anesthesia: A double-blind, randomized study:

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0008314

Enrollment

Registered

2023-03-22

Start date

2023-03-16

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : In the propofol group, a target controlled infusion of 4 µg/ml of propofol and a target controlled infusion of 4 ng/ml of remifentanil were continuously intravenously infused using an infusion

Fresenius Vial, France), and then loss of consciousness was confirmed. 0.3 mg/kg of rocuronium is administered and intubation is performed. Maintain anesthesia by adjusting the infusion rate of propof

Fresenius Vial, France), 12 mg/kg/h of remimazolam and 4 ng/ml of targeted controlled infusion of remifentanil are continuously injected intravenously, and then the loss of consciousness is confirmed.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Patients undergoing ambulatory gynecological surgery under general anesthesia or gynecological surgery that is expected to take less than 30 minutes 2) Adult female patients aged 20-60 years 3) American Society of Anesthesiology Classification 1,2 patients 4) Patients who gave informed consent to the study

Exclusion criteria

Exclusion criteria: 1) American Society of Anesthesiologists (ASA) physical classification III or higher 2) BMI > 40kg/m2 3) If you are allergic to remimazolam or profopol or to other drugs used in the study (benzodiazepines, propofol, remifentanil, fentanyl citrate, rocuronium bromide, sugammadex, flumazenil) 4) If the operation is expected to last more than 2 hours 5) If antidepressants, psychiatric medications, rifampicin, succinycholine, neostigmine, flumazenil, or cyclosporin are administered before surgery 6) If you have a serious illness that can affect your systemic condition, including cancer or cardiopulmonary, liver, or kidney disease. 7) Patients with galactose intolerance or lactase deficiency or glucose-galactose malabsorption 8) Patients with medical or psychological diseases that may affect treatment response, patients with life-span disorders 9) Pregnant women

Design outcomes

Primary

Measure	Time frame
The time from when the anesthetic is stopped until the patient opens their eyes	—

Secondary

Measure	Time frame
Time from discontinuation of anesthesia to extubation, time from completion of surgery to discharge	—

Countries

Korea, Republic of

Contacts

Public ContactEunsu Choi

Korea University Ansan Hospital

potterydoll@hanmail.net+82-31-412-5297

Outcome results