None listed
Conditions
Interventions
Drug : In the control group, normal saline is injected intravenously as a placebo.
In the experimental group, lidocaine is intravenously administered with the rate of 1.5 mg/kg/hr after loading of 1
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 70 (19-69 years old ) (2) American society of anesthesiologist physical status I, II
Exclusion criteria
Exclusion criteria: (1) history of adverse events or allergic to lidocaine and dexmedetomidine (2) obese: Body Mass Index = 35 kg/m2 (3) cardiovascular disease: severe cardiac dysfunction, bradycardia, atrioventricular block, coronary artery disease (4) electrolyte imbalance (5) significant hepatic/renal impairment (6) neurological disorder: seizure, central nervous system disease (7) History of medication: opioid, a2 agonist, alcohol abuse, antidepressant (8) psychiatric disorder or inability to comprehend the study protocols (9) pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| opioid consumption during 24h after surgery (morphine equivalent dose) | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative opioid consumption (morphine equivalent dose);Resting pain severity (Numeric rating scale: 11point scale, 0= no pain, 10= worst imaginable pain) ;opioid related side efffect (nausea and vomiting, dizziness, somnolence, and respiratory depression);Time to first flatus;Time to weaning for normal diet ;antiemetics admnistration ;composite of any complication;recovery from anesthesia and surgery (QoR15K);recovery profile at emergence (time to emergence, time to extubation, coughing grade);emergence delirium (RASS) | — |
Countries
Korea, Republic of
Contacts
Public ContactYu Jeong Bang
Samsung Medical Center
Outcome results
None listed