None listed
Conditions
Interventions
Dietary Supplement : 1) Color, Shape and Dosage Form: white powder, white rectangular hard capsule
2) Content: 300 mg/tablet
3) Storage: Room temperature
4) Usage and Dosage: once a day, 3 tablets onc
Sponsors
COSMAX BIO
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adult men and women between the ages of 30 and 65 2) A person with a grade of wrinkles around the eyes of Grade 3 or higher based on the Crow's feet wrinkle photo scale 3) A person whose cheek moisture retention was measured with Corneometer® CM825 at Visit 1 and Visit 2 and the result value was 49 A.U. (Arbitrary Unit) or less 4) A person who consented to participate in this clinical trial and filled out the Informed Consent Form before the clinical trial started 5) A person who can be followed up during the study period
Exclusion criteria
Exclusion criteria: 1) A person who is a currently being treated for severe cardiovascular, immune, respiratory, gastrointestinal/liver and biliary tract, kidney and urinary, nervous, musculoskeletal, infectious diseases and malignant tumors, etc. 2) A person with mental illness such as schizophrenia, depression, drug addiction, and alcohol use/induced disorders, etc. 3) A person with skin diseases such as atopic dermatitis and psoriasis,etc. 4) A person with skin abnormalities such as moles, acne, erythema, telangiectasia, etc. in the area to be tested 5) Based on visit 1, a person who has undergone facial botox or filler treatment within 6 months, or who have received facial laser treatment, skin peeling, or other skin care within 1 month (30 days) 6) Based on visit 1, a person who has used steroid-containing skin exfoliation agents on the facial area or have taken oral retinoid/steroid agents within 1 month 7) Based on visit 1, a person who has taken anti-obesity drugs (fat absorption inhibitors, appetite suppressants, etc.), psychiatric drugs such as depression and schizophrenia, contraceptives, hormones, or diuretics within 1 month 8) Based on visit 1, a person who consumed medicines and health functional foods(Health functional food containing antioxidants, hyaluronic acid, collagen, evening primrose oil, medicines and health functional foods containing vitamins A, C, and E, etc.) for the purpose of skin wrinkle improvement and moisturizing effect within 2 weeks 9) Based on visit 1, a person who has used functional cosmetics for wrinkle improvement (retinoids, AHAs, etc.), highly moisturizing cosmetics, or skin care devices (LED mask, ion booster, etc.) within 2 weeks 10) A person with AST (GOT) or ALT (GPT) of 120 IU/L or more or ?-GTP of 180 IU/L or more 11) A person with creatinine of 2.4 mg/dL or higher 12) A person with TSH below 0.1 µIU/mL or above 10 µIU/mL 13) A person with uncontrolled diabetes (fasting blood sugar over 180mg/dL) 14) Pregnant or lactating women or those who plan to become pregnant during this human study 15) Based on visit 1, a person who has participated in other interventional clinical trials (including human studies) within 1 month, or plan to participate in other interventional clinical trials (including human studies) after the start of this human study 16) A person who is sensitive or allergic to food ingredients for this human study 17) A person who is judged unsuitable by the tester for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin Wrinkles; Moisture Content in Deep Skin; Skin Elasticity;Transepidermal Water Loss (TEWL);Skin Melanin; Evaluation of Improvement after Test Substance Ingestion by Investigators;Evaluation of Improvement after Test Substance Ingestion by Subjects;Skin Hydration | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety Variables : 1) Adverse Reaction 2) Clinical Laboratory Test(Hematological/Hematochemical Test, Urinalysis) | — |
Countries
Korea, Republic of
Contacts
Public ContactJuhee Lee
Yonsei University Health System, Severance Hospital
Outcome results
None listed