A comparison of midazolam and dexmedetomidine on postoperative delirium in patients undergoing two-staged bilateral total knee replacement under spinal anesthesia: a cross over study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0008227

Enrollment

Registered

2023-02-23

Start date

2023-03-01

Completion date

Unknown

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : intravenous midazolam or dexmedetomidine are intravenously administered for procedural sedation during TKR under spinal anesthesia at one-week interval

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) informed consent and voluntary participation 2) aged 65-85 years 3) patients undergoing spinal anesthesia for bilateral staged total knee arthroplasty at one week interval

Exclusion criteria

Exclusion criteria: 1) psychologic disorder including schizophrenia, epilepsy, parkinson's disease and dememtia 2) K-MMSE score < 20 3) severe bradycardia (<45 bpm), sick sinus syndrome, type 2 or 3 degree AV block 4) severe hepatic dysfunction 5) severe renal dysfunction 6) history of recent stroke (within 6 months) 7) alcohol or drug dependency 8) difficulty of conmmunication 9) want general anesthesia 10) ASA PS 4-5

Design outcomes

Primary

Measure	Time frame
incidence of postoperative delirium	—

Secondary

Measure	Time frame
severity of postoperative delirium	—

Countries

Korea, Republic of

Contacts

Public ContactA Ram Doo

Jeonbuk National University Hospital

ruiwin3518@gmail.com+82-63-250-1249

Outcome results