None listed
Conditions
Interventions
Drug : Patients diagnosed with major depressive disorder are recruited from the outpatient department of psychiatry at Chung-Ang University Hospital. Patients with major depressive disorder with acute
Sponsors
Chung-Ang Univerisity Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? The age of 18 to 65 ? A person diagnosed as a major depressive disorder without psychotic features. by Structured Clinical Interview for DSM-5 (SCID-5) ? BAI scale score is 16 or higher (with moderate or higher anxiety symptoms) ? Those who have no history of using Mirtazapine in the last two months based on the initial evaluation point ? Those who have been administering antidepressants (SSRI, SNRI and NDRI) at stable doses for more than 1 month
Exclusion criteria
Exclusion criteria: ? A person who has been diagnosed other psychiatric diagnosis by SCID-5-CV in the past ? Those who currently have severe medical conditions (cancer, heart failure, kidney failure, liver disease, lung disease, thyroid disease and acute inflammatory conditions) ? A person who has a history of past or present dependence on substances or misuse ? A person with a history of epilepsy, head trauma, and organic mental illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean change of Beck anxiety inventory (BAI) scores from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| mean change of Beck depressive inventory (BDI-II) scores from baseline;mean change of Korean Symptom Check List 95 (KSCL95) scores from baseline;mean change of CGI-S scores from baseline;CGI-I scores after 8 weeks of intervention;hemodynamic changes in prefrontal cortex measured with functional Near-Infrared Spectroscopy(fNIRS) | — |
Countries
Korea, Republic of
Contacts
Public ContactHee Jin KIM
Chung-Ang Univerisity Hospital
Outcome results
None listed