None listed
Conditions
Interventions
Drug : Patients with CRAB bacteremia enrolled in this clinical trial will be randomly assigned to one of the two treatment groups below.
• Group 1: Ampicillin/sulbactam 6g IV q6h + colistin (5mg/kg I
Sponsors
Seoul National University Bundang Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who has signed a consent : If the patients is unable to provide the consent due to medical conditions, the patient's representative may provide the consent on behalf of the patient if permitted by local law and the standard work instructions. 2) An adult male or female aged 19 years or older as of the date of written consent 3) Patients who were confirmed Acinetobacter baumannii bacteremia by blood cultures using using peripheral blood or central venous blood before 96 hours of randomization.
Exclusion criteria
Exclusion criteria: 1) Patients with baceremia of other than Acinetobacter baumanii within 7 days 2) Patients who has been identified with bacteremia of multiple strains 3) Patients who has been treated for CRAB infection within 14 days 4) Paitents who has previously had a significant hypersensitivity to colistin or ampicillin/sulbactam 5) Patients who had received another clinical trial drug within 28 days 6) Patients who administred CRAB susceptible antibiotics including colistin for more than 72 hours immediately before taking the clinical trial drug, 7) Patients with pregnant or breast-feeding 8) Patients who are expected to die within 2 days after randomization by the investigator 9) Patients deemed unsuitable for participation in this clinical trial based on the medical opinion of the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical failure;All-cause mortality;Disease-specific mortality;Days to microbiological eradication;Days to resolution of fever;ICU length of stay;Days to discharge | — |
Countries
Korea, Republic of
Contacts
Public ContactSeong Jin Choi
Seoul National University Bundang Hospital
Outcome results
None listed