None listed
Conditions
Interventions
None listed
Sponsors
Chonnam National University Hospital Hwasun Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Histologically confirmed loco-regional rectal adenocarcinoma (cT3-4,Nany) Male and female participants >=18 and <=80 of age inclusive, at the time of signing the informed consent Radiologically confirmed cT3, CRM positive or T4 or unresectable in rectal MRI(enhance)
Exclusion criteria
Exclusion criteria: Structurally bowel obstruction lesion or impending feature bowel perforation or grade >= hemorrhage or bleeding event History of distant metastatic lesions Grade >=1 of CTC-AE Uncontrolled significant cardiovascular disease or unstable angina or myocardial infarction or unstable arrhythmia or hepatitis or coagulopathy risk or psychosis prior to initiation of study treatment Known allergy or hypersensitivity to fluoropyrimidine or platinum drugs or their excipients Known DPD deficiency identified Prior clinical study within 4 weeks prior to initiation of study treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ctDNA, mrTRG on rectal MRI, patologic CR | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free survival, overall survival | — |
Countries
Korea, Republic of
Contacts
Public ContactYu Bin Kim
Chonnam National University Hospital Hwasun Hospital
Outcome results
None listed