None listed
Conditions
Interventions
Drug : In order to induce general anesthesia, inject Remimazolam prepared at a concentration of 1 mg/ml as a bolus through a syringe pump at a dose calculated in advance for about 1 minute.
If the
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Female patients (20-39 years old group, 40-59 years old group, 60-75 years old group ) who correspond to ASA 1 and 2, weight <100 kg, and are scheduled to general anesthesia.
Exclusion criteria
Exclusion criteria: Patients with BMI > 30 kg/m2 or < 20 kg/m2, patients with contraindications such as allergies to this study drug, patients with hearing impairment, etc., who are unable to respond to the researcher's verbal command, or patients with liver disease (bilirubin =3.0 mg/dl, or aspartate amino transferase/alanine aminotransferase = 2.5 x upper limits of normal), renal disease (creatine = 2 mg/dl), chronic obstructive pulmonary disease, uncontrolled hypertension ( e.g. Patients with systolic BP =160 mmHg), diabetes (HbA1c = 9%), moderate to severe coronary artery disease, glaucoma, heart failure, or taking other medications that may affect the effectiveness of benzodiazepines despite taking blood pressure medications If present, a history of smoking (within the last 6 months). If the IV line is placed on the back of the hand.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in EC50 and EC95 for anesthesia induction effect in each group | — |
Secondary
| Measure | Time frame |
|---|---|
| Check loss of consciousness (LOC) every 10 seconds for 90 seconds after drug administration;Difference in time to LOC in each group;Differences in the occurrence of postoperative nausea and vomiting (PONV) and the degree of pain in each group of patients | — |
Countries
Korea, Republic of
Contacts
Public ContactEunji Ha
Ajou University Hospital
Outcome results
None listed