None listed
Conditions
Interventions
None listed
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult men and women over the age of 45 2. After listening to and fully understanding the detailed explanation of this study, the subject or legal representative voluntarily decides to participate in the study and gives written consent Subjective Cognitive Dysfunction (SCD) 1. MMSE score above mean-1 SD when considering age, gender, and education level 2. A willing and viable subject to cooperate with this study and complete all clinical trial stages Mild cognitive impairment (MCI) 1. Patient or guardian complains of cognitive impairment 2. Confirmation that cognitive ability including memory is lower than age and education through neuropsychological test (aMCI) Disorder (naMCI) 3. Maintain overall cognitive function 4. No disruption to daily life 5. Dementia must not be determined by the clinician. Alzheimer's type dementia patients (AD) 1. Probable AD dementia in the NIA-AA diagnostic guidelines for AD: Patients who satisfy the core clinical criteria and have an MMSE score of 10 or higher Frontotemporal dementia (FTD) dementia 1. FTD includes bvFTD, nfvPPA, svPPA, according to their respective criteria. - bvFTD: according to the standard suggested by Bruce miller et al. - svPPA, nfvPPA : M.L. According to the criteria suggested by Gorno-Tempini et al.
Exclusion criteria
Exclusion criteria: Exclusion from this study is required if one or more of the following conditions are met 1) Patients with neurological abnormalities that may cause memory impairment on medical examination 2) Those with a history of uniaxial psychiatric disorders including intellectual disability, schizophrenia, alcoholism, and bipolar disorder in the past 3) Those with a history of malignant disease (cancer) within the last 3 years. Except for cervical carcinoma in situ or non-melanoma skin cancer. 4) Those who have undergone cerebrovascular surgery, such as brain surgery or carotid artery surgery 5) Those who have neurological symptoms that are evidence of cerebrovascular disease, such as extrapyramidal signs consistent with subcortical lesions. 6) Those who have clear white matter on MRI. Distinctive white matter should conform to the following definition. Periventricular lesions measured in parallel with the ventricles should be 10 mm or more (extended cap) or an irregular edge and an irregular halo of more than 10 mm (irregular halo). change) or a local lesion, but more than an extensive deep white matter change. 7) Those who have difficulty breathing when sitting still 8) Those who have had memory impairment, speech impairment, or problem-solving ability for more than 2 hours after a heart attack 9) Those who have been hospitalized for mental or emotional illness within the past 5 years 10) Those with a history of drug abuse within the last 5 years 11) Those with a history of treatment for alcoholism within the past 5 years 12) Those who have lost consciousness for more than 1 hour due to causes other than general anesthesia 13) Those who have been hospitalized with head injuries 14) Those who cannot read normally even with glasses due to reduced vision 15) Those who have difficulty understanding conversations due to hearing impairment even with hearing aids 16) Pregnant and lactating women 17) Other investigators who are judged inappropriate to participate in clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demographic, clinical information (neuropsychological test, blood test, brain imaging test, genetic test) | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic, clinical information (neuropsychological test, blood test, brain imaging test, genetic test) | — |
Countries
Korea, Republic of
Contacts
Public ContactBo Kyoung Cheon
Samsung Medical Center
Outcome results
None listed