Preventive multimodal analgesic effect of combined acetaminophen and ibuprofen for acute and chronic pain after breast cancer surgery: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0007928

Enrollment

Registered

2022-11-22

Start date

2022-11-29

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : After induction of anesthesia, the test drug (Maxigesic or saline) is administered according to group allocationl before the initiation of surgical incision. Investigational drug: Maxigesic 100

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A 20-80-year-old female patient with physical condition classification 1-2 of the American Society of Anesthesiologists undergoing breast conserving surgery

Exclusion criteria

Exclusion criteria: abnormality of liver function (AST or ALT 60 IU/L or more) renal function deterioration (GFR 60ml/hr or less) allergic to acetaminophen or nonsteroidal anti-inflammatory drugs history of gastrointestinal ulcers or gastrointestinal bleeding coagulation lab abnormalities (collagen/epinephrine > 257, PT INR > 1.15, aPTT > 45) heart failure patients history of bronchial asthma pregnant Those who taking barbituric drugs, tricyclic antidepressants, and high-dose methotrexate use of intravenous patient controlled analgesic device lumpectomy without lymph node dissection Diseases that may indicate neuralgia of the upper extremities and upper body (cervical spine disease, herpes zoster, thoracic outlet syndrome, etc.) Those who refused to participate in this study

Design outcomes

Primary

Measure	Time frame
Morphine equivalent dose	—

Secondary

Measure	Time frame
pain scoring, postoperative nausea/vomiting, and use of antiemetics	—

Countries

Korea, Republic of

Contacts

Public ContactJiwon Han

Chung-Ang University

yesuroon@gmail.com+82-2-2222-1533

Outcome results