None listed
Conditions
Interventions
None listed
Sponsors
Asan Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria - Participants were eligible for inclusion if all of the following criteria were met: 1. Adults aged =18 and <80 years. 2. Documented history of SARS-CoV-2 infection confirmed by PCR or antigen testing at least 3 months prior to enrollment, or no prior history of SARS-CoV-2 infection (control group).
Exclusion criteria
Exclusion criteria: Exclusion criteria Participants were excluded if any of the following criteria were present: 1. History of cognitive complaints or cognitive impairment prior to SARS-CoV-2 infection. 2. Acute illnesses within the past 2 months, including but not limited to myocardial infarction, unstable angina, pneumonia, or other acute infectious diseases. 3. Active malignancy. 4. Autoimmune diseases requiring immunosuppressive therapy. 5. Neurodegenerative disorders, including but not limited to Alzheimer’s disease or Parkinson’s disease. 6. Major psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in grey matter thickness: Brain MR | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in orthostatic intolerance: Autonomic function test (Tilt test);Change in cognitive dysfunction: SNSB;Impact of post-COVID19 neuropsychological sequelae in Quality-of-life, depression/anxiety, sleep, and fatigue: Quality-of-life EQ-5D-5L; Depression MADRS; Depression/anxiety HADS; Sleep PSQI-K; Fatigue FAS(screening) and DSQ-SF(follow-up); Cognition K-AD8(screening) and SNSB(follow-up) ;Exploratory analysis on neuro-specific and inflammatory immune profile: Serum and PBMC | — |
Countries
Korea, Republic of
Contacts
Public ContactDayoung Seo
Asan Medical Center
Outcome results
None listed