None listed
Conditions
Interventions
None listed
Sponsors
Yonsei University Health System, Severance Hospital
Korea University Anam Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients over 19 years of age who have been diagnosed with degenerative arthritis, specifically spondyloarthritis or osteoarthritis of the knee, who have been prescribed non-selective NSAIDs for at least 4 weeks. 2) Patients who have not been given Cox2-selective NSAIDs in the treatment of degenerative arthritis within the last 2 weeks. 3) Patients confirmed to have symptomatic osteoarthritis through medical history, with a pain VAS score is greater than 40 mm prior to participant registration. 4) Individuals who voluntarily agree to participate in this study, who can understand the information provided to them, and who can sign the consent form willingly.
Exclusion criteria
Exclusion criteria: 1) A person diagnosed with a clinically significant mental illness and receiving medication. 2) Patients with severe gastrointestinal diseases (such as gastric ulcers) as judged by the investigator. 3) Patients with established ischemic heart disease, peripheral arterial disease, or cerebrovascular disease, or those with a high risk of severe cardiovascular adverse reactions (such as heart attack, myocardial infarction, stroke) as judged by the investigator. 4) Patients scheduled for surgery during the clinical trial period. 5) Patients with a history of allergies to any components of the clinical research medication. 6) Patients with malignant tumors or other serious health conditions that may result in a life expectancy of less than 6 months. 7) Patients who have participated in another clinical trial within the last 4 weeks prior to the study. 8) Participants who are unable to comply with the clinical research procedures specified in the study protocol. 9) Any other individuals deemed unsuitable for participation in this clinical research based on the medical opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 100mm Pain VAS Variation;EQ-5D-5L Variation | — |
Secondary
| Measure | Time frame |
|---|---|
| 100mm Pain VAS Variation;EQ-5D-5L Variation;ODI change in case of osteoarthritis;K-WOMAC [22] change in case of gonarthritis;Overall drug discontinuation rate;drug discontinuation rate according to Satisfied with pain control;drug discontinuation rate according to AE;drug discontinuation rate according to insufficient effect | — |
Countries
Korea, Republic of
Contacts
Public ContactSeonghwan Moon
Yonsei University Health System, Severance Hospital
Outcome results
None listed